Developmental neurobiology: New concepts memory, and neuronal development

Karen H. Harum, Michael V. Johnston

Research output: Contribution to journalReview articlepeer-review

Abstract

Increasing research efforts and rapidly expanding knowledge in the neuroscientific foundations of learning, memory, and developmental disabilities have provided insights into the normal development and plasticity of neuronal circuits. Likewise, the neurobiologic and molecular genetic substrates of developmental disabilities and mental retardation syndromes are unfolding and leading to potential manipulations of these disorders in children with developmental disabilities. This review highlights the mechanisms of synaptic plasticity, long-term potentiation, and molecular mechanisms of memory. Some mental retardation syndromes due to abnormal genetic regulation are mentioned.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalMental Retardation and Developmental Disabilities Research Reviews
Volume4
Issue number1
DOIs
StatePublished - 1998

Keywords

  • Cortical development
  • Long-term potentiation
  • Memory
  • Synaptic plasticity
  • Transcriptional regulation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Genetics(clinical)

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