Developmental maturation of chemosensitivity to hypoxia of peripheral arterial chemoreceptors

Estelle B. Gauda, John L. Carroll, David F. Donnelly

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Peripheral arterial chemoreceptors, particularly the carotid body chemoreceptors, are the primary sites for the detection of hypoxia and reflexly increase ventilatory drive and behavioral arousal during hypoxic or asphyxial events. Newborn infants are at risk for hypoxic and asphyxial events during sleep, yet, the strength of the chemoreceptor responses is low or absent at birth and then progressively increases with early postnatal development. This review summarizes the available data showing that even though the "oxygen sensor" in the glomus cells has not been unequivocally identified, it is clear that development affects many of the other properties of the chemoreceptor unit (glomus cell, afferent nerve fibers and neurotransmitter profile at the synapse) that are necessary and essential for the propagation of the "sensing" response, and exposure to hypoxia, hyperoxia and nicotine can modify normal development of each of the components leading to altered peripheral chemoreceptor responses.

Original languageEnglish (US)
Title of host publicationArterial Chemoreceptors
EditorsConstancio Gonzalez, Colin Nurse, Chris Peers
Pages243-255
Number of pages13
DOIs
StatePublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
Volume648
ISSN (Print)0065-2598

Keywords

  • Acetylcholine
  • Adenosine
  • Afferent fibers
  • Calcium responses
  • Carotid body
  • Chemoreception
  • Cholinergic
  • Development
  • Dopamine
  • Dopaminergic
  • Environment
  • Glomus cells
  • Hypoxia
  • New born
  • PO
  • Reflexes
  • Sleep
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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