Developmental expression of the amyloid precursor protein, growth-associated protein 43, and somatostatin in normal and trisomy 16 mice

Bruce F. O'Hara, Shannon Fisher, Mary Lou Oster-Granite, John D. Gearhart, Roger H Reeves

Research output: Contribution to journalArticle

Abstract

The expression during development of 3 genes located on mouse chromosome 16 (MMU 16) which are implicated in neurobiological processes was examined by blot hybridization beginning at early gestational ages in the mouse. The 3 genes, amyloid precursor protein (App), preprosomatostatin (Smst), and growth-associated protein 43 (Gap43), exhibited distinct profiles of expression. App expression increased steadily throughout fetal and postnatal development, Smst expression peaked during the third postnatal week, then reached a plateau at a slightly lower level in adults, and Gap43 expression was highest in the early postnatal period, declining in adults to levels below those seen at the earliest timepoints examined. Smst message levels exhibited a 1.5-fold increase in the brains of trisomy 16 (Ts16) mice as compared to normal littermates on day 15 of gestation, while Gap43 and App message levels were elevated approximately 2-fold.

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalDevelopmental Brain Research
Volume49
Issue number2
DOIs
Publication statusPublished - Oct 1 1989

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Keywords

  • Amyloid
  • Development
  • Down syndrome
  • Gap43
  • Somatostatin
  • Trisomy 16

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

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