Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats

Tomas R. Guilarte; Renée C. Miceli; Timothy H. Moran

doi:10.1016/0361-9230(91)90249-J

Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats

Tomas R. Guilarte, Renée C. Miceli, Timothy H. Moran

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The nocturnal spontaneous locomotor behavior of vitamin B-6 restricted and control rats was measured using activity chambers. The results show a generalized hypoactivity in indices of horizontal and vertical activity in neonatal rats fed vitamin B-6 restricted diets during gestation and lactation. This pattern of locomotor behavior changed in the postweaning period to a gradual increase in indices of locomotor activity to a pronounced hyperkinesis in vitamin B-6 restricted young adult rats. This study suggests that long-term vitamin B-6 restriction results in damage and/or abnormal development of neuronal system(s) associated with locomotor behavior.

Original language	English (US)
Pages (from-to)	857-861
Number of pages	5
Journal	Brain Research Bulletin
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/0361-9230(91)90249-J
State	Published - Jun 1991

Keywords

Deficiency
Development
Hyperactivity
Locomotor behavior
Rats
Vitamin B-6

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0361-9230(91)90249-J

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title = "Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats",

abstract = "The nocturnal spontaneous locomotor behavior of vitamin B-6 restricted and control rats was measured using activity chambers. The results show a generalized hypoactivity in indices of horizontal and vertical activity in neonatal rats fed vitamin B-6 restricted diets during gestation and lactation. This pattern of locomotor behavior changed in the postweaning period to a gradual increase in indices of locomotor activity to a pronounced hyperkinesis in vitamin B-6 restricted young adult rats. This study suggests that long-term vitamin B-6 restriction results in damage and/or abnormal development of neuronal system(s) associated with locomotor behavior.",

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AU - Miceli, Renée C.

AU - Moran, Timothy H.

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AB - The nocturnal spontaneous locomotor behavior of vitamin B-6 restricted and control rats was measured using activity chambers. The results show a generalized hypoactivity in indices of horizontal and vertical activity in neonatal rats fed vitamin B-6 restricted diets during gestation and lactation. This pattern of locomotor behavior changed in the postweaning period to a gradual increase in indices of locomotor activity to a pronounced hyperkinesis in vitamin B-6 restricted young adult rats. This study suggests that long-term vitamin B-6 restriction results in damage and/or abnormal development of neuronal system(s) associated with locomotor behavior.

KW - Deficiency

KW - Development

KW - Hyperactivity

KW - Locomotor behavior

KW - Rats

KW - Vitamin B-6

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Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats

Abstract

Keywords

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