Developmental changes in upper airway dynamics

Carole L. Marcus, Lucila B. Fernandes Do Prado, Janita Lutz, Eliot S. Katz, Cheryl A. Black, Patricia Galster, Kathryn Anne Carson

Research output: Contribution to journalArticle

Abstract

Normal children have a less collapsible upper airway in response to subatmospheric pressure administration (PNEc) during sleep than normal adults do, and this upper airway response appears to be modulated by the central ventilatory drive. Children have a greater ventilatory drive than adults. We, therefore, hypothesized that children have increased neuromotor activation of their pharyngeal airway during sleep compared with adults. As infants have few obstructive apneas during sleep, we hypothesized that infants would have an upper airway that was resistant to collapse. We, therefore, compared the upper airway pressure-flow (V) relationship during sleep between normal infants, prepubertal children, and adults. We evaluated the upper airway response to 1) intermittent, acute PNEG (infants, children, and adults), and 2) hypercapnia (children and adults). We found that adults had a more collapsible upper airway during sleep than either infants or children. The children exhibited a vigorous response to both PNEG and hypercapnia during sleep (P <0.01), whereas adults had no significant change. Infants had an airway that was resistant to collapse and showed a very rapid response to P NEG. We conclude that the upper airway is resistant to collapse during sleep in infants and children. Normal children have preservation of upper airway responses to PNEG and hypercapnia during sleep, whereas responses are diminished in adults. Infants appear to have a different pattern of upper airway activation than older children. We speculate that the pharyngeal airway responses present in normal children are a compensatory response for a relatively narrow upper airway.

Original languageEnglish (US)
Pages (from-to)98-108
Number of pages11
JournalJournal of Applied Physiology
Volume97
Issue number1
DOIs
StatePublished - Jul 2004

Fingerprint

Sleep
Hypercapnia
Pressure
Obstructive Sleep Apnea
Drive

Keywords

  • Children
  • Critical pressure
  • Infants
  • Sleep-disordered breathing
  • Upper airway collapsibility

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Marcus, C. L., Fernandes Do Prado, L. B., Lutz, J., Katz, E. S., Black, C. A., Galster, P., & Carson, K. A. (2004). Developmental changes in upper airway dynamics. Journal of Applied Physiology, 97(1), 98-108. https://doi.org/10.1152/japplphysiol.00462.2003

Developmental changes in upper airway dynamics. / Marcus, Carole L.; Fernandes Do Prado, Lucila B.; Lutz, Janita; Katz, Eliot S.; Black, Cheryl A.; Galster, Patricia; Carson, Kathryn Anne.

In: Journal of Applied Physiology, Vol. 97, No. 1, 07.2004, p. 98-108.

Research output: Contribution to journalArticle

Marcus, CL, Fernandes Do Prado, LB, Lutz, J, Katz, ES, Black, CA, Galster, P & Carson, KA 2004, 'Developmental changes in upper airway dynamics', Journal of Applied Physiology, vol. 97, no. 1, pp. 98-108. https://doi.org/10.1152/japplphysiol.00462.2003
Marcus CL, Fernandes Do Prado LB, Lutz J, Katz ES, Black CA, Galster P et al. Developmental changes in upper airway dynamics. Journal of Applied Physiology. 2004 Jul;97(1):98-108. https://doi.org/10.1152/japplphysiol.00462.2003
Marcus, Carole L. ; Fernandes Do Prado, Lucila B. ; Lutz, Janita ; Katz, Eliot S. ; Black, Cheryl A. ; Galster, Patricia ; Carson, Kathryn Anne. / Developmental changes in upper airway dynamics. In: Journal of Applied Physiology. 2004 ; Vol. 97, No. 1. pp. 98-108.
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