Developmental changes in impulse conduction in the canine heart.

M. R. Rosen, M. J. Legato, R. M. Weiss

Research output: Contribution to journalArticle

Abstract

We studied the age-related changes that occur in conduction in Purkinje fiber bundles (PF) from adult and 8-wk-old dogs. As PF are stretched, conduction velocity increases to a maximum when bundle length is approximately 1.5 times control. Conduction velocity in adult PF was significantly faster than that in 8-wk PF at all bundle lengths, the maximum being 2.32 +/- 0.45 m/s (mean +/- SD) in adult and 1.56 +/- 0.59 m/s in 8-wk-old dogs. At greater than 1.5 times control length, conduction velocity decreased, as did resting potential, action potential amplitude, and upstroke velocity. At 1.5 times control length, the ratio of PF to collagen in the bundles increased, and structural changes consistent with both unbuckling and unfolding of the cell membranes were seen. At greater degrees of stretch, cleft size diminished, and intracellular edema was noted. In sum, structural changes in cardiac PF can explain the changes in conduction velocity that occur with stretch. At all degrees of stretch, however, velocity is faster in PF from adult than from young dogs.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume240
Issue number4
StatePublished - Apr 1981
Externally publishedYes

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Purkinje Fibers
Canidae
Dogs
Membrane Potentials
Action Potentials
Young Adult
Edema
Collagen
Cell Membrane

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Developmental changes in impulse conduction in the canine heart. / Rosen, M. R.; Legato, M. J.; Weiss, R. M.

In: The American journal of physiology, Vol. 240, No. 4, 04.1981.

Research output: Contribution to journalArticle

Rosen, M. R. ; Legato, M. J. ; Weiss, R. M. / Developmental changes in impulse conduction in the canine heart. In: The American journal of physiology. 1981 ; Vol. 240, No. 4.
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