Developmental, behavioral, and physiological phenotype of cloned mice

Kellie L.K. Tamashiro, Randall R. Sakai, Yukiko Yamazaki, Teruhiko Wakayama, Ryuzo Yanagimachi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cloning from adult somatic cells has been successful in at least ten species. Although generating viable cloned mammals from adult cells is technically feasible, prenatal and perinatal mortality is high and live cloned offspring have had health problems. This chapter summarizes the health consequences of cloning in mice and discusses possible mechanisms through which these conditions may arise. These studies have further significance as other assisted reproductive techniques (ART) also involve some of the same procedures used in cloning, and there are some reports that offspring generated by ART display aberrant phenotypes as well. At the moment, the long-term consequences of mammalian cloning remain poorly characterized. Data available thus far suggest that we should use this technology with great caution until numerous questions are addressed and answered.

Original languageEnglish (US)
Title of host publicationSomatic Cell Nuclear Transfer
PublisherSpringer New York
Pages72-83
Number of pages12
ISBN (Print)9780387377537
DOIs
StatePublished - 2007

Publication series

NameAdvances in Experimental Medicine and Biology
Volume591
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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