Developmental assessment of infants with biliary atresia: Differences between boys and girls

Susan E. Caudle, Jennifer M. Katzenstein, Saul Karpen, Valérie McLin

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The aim of the present study was to investigate whether male and female infants with biliary atresia (BA) differ cognitively and to confirm previously documented developmental lags in infants with BA before liver transplantation. Methods: With the Mullen Scales of Early Learning, we examined 21 female and 12 male infants (ages 3-20 months) with BA, comparing scores across indices by sex and correlating Mullen Scales of Early Learning scores with standard clinical and biochemical parameters. Results: Overall, both boys and girls were found to be vulnerable to developmental lags in the areas of expressive language (EL) and gross motor skills. In comparison with their male peers, girls were found to be weaker in the area of visual reception skills (P=0.05) with a trend found for EL (P=?0.08). Girls were also found to have higher C-bilirubin levels and to be of shorter length. Growth parameters were found to be correlated with EL scores. International normalized ratio was found to be correlated with gross motor performance and with a trend also noted for fine motor skills. Age at Kasai predicted receptive language skills. Conclusions: As has been shown, infants with BA appear to be vulnerable to developmental lags before transplantation. In particular, female infants appear to be vulnerable to cognitive and skill delays in comparison with their male peers. C-bilirubin levels may play a role in this increased vulnerability for females.

Original languageEnglish (US)
Pages (from-to)384-389
Number of pages6
JournalJournal of pediatric gastroenterology and nutrition
Volume55
Issue number4
DOIs
StatePublished - Oct 2012
Externally publishedYes

Keywords

  • Biliary atresia
  • Cognitive outcome
  • Language
  • Motor
  • Sex

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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