Development of vaccines and their use in the prevention of fungal infections

D. M. Dixon, Arturo Casadevall, B. Klein, L. Mendoza, L. Travassos, G. S. Deepe

Research output: Contribution to journalArticle

Abstract

Vaccine approaches to infectious diseases are widely applied and appreciated. Disciplines such as bacteriology and virology have a rich history of successful vaccine development. The complexity of eukaryotic systems presents additional challenges to the development of vaccines against them. These challenges are being met in the fields of parasitology, and are being revisited for application in oncology. Vaccine opportunities exist in medical mycology. The National Institute of Allergy and Infectious Diseases has held a series of workshops in medical mycology where the need to develop vaccines for fungal diseases was noted and where important opportunities were discussed. Major advances in vaccinology and the technology of antigen preparation and delivery have increased feasibility and heightened interest. The recent epidemic of coccidioidomycosis in the American Southwest has demonstrated the need for developing a vaccine as an effective preventive measure for those living in and for those who subsequently move into regions with the endemic mycoses. The XIIth Congress of the International Society for Human and Animal Mycology included a symposium that summarized new vaccination strategies for selected fungi: Candida albicans, Coccidioides immitis, and Trichophyton verrucosum. The goal of the present summary is to provide representative examples of continuing efforts relating to vaccine development within the medical mycological community highlighting Blastomyces dermatidis, Cryptococcus neoformans, Histoplasma capsulatum, Paracoccidioides brasiliensis and Pythium insidiosum.

Original languageEnglish (US)
Pages (from-to)57-67
Number of pages11
JournalMedical Mycology, Supplement
Volume36
Issue number1
StatePublished - 1998
Externally publishedYes

Fingerprint

Mycoses
vaccine development
mycology
Vaccines
Mycology
vaccines
infection
infectious diseases
Blastomyces
Pythium insidiosum
Coccidioides immitis
Trichophyton verrucosum
coccidioidomycosis
Histoplasma capsulatum
Paracoccidioides brasiliensis
virology
parasitology
bacteriology
Southwestern United States
Cryptococcus neoformans

Keywords

  • Immunization
  • Mycoses
  • Prevention
  • Pythiosis
  • Therapeutic
  • Vaccines

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Agricultural and Biological Sciences (miscellaneous)
  • veterinary(all)

Cite this

Dixon, D. M., Casadevall, A., Klein, B., Mendoza, L., Travassos, L., & Deepe, G. S. (1998). Development of vaccines and their use in the prevention of fungal infections. Medical Mycology, Supplement, 36(1), 57-67.

Development of vaccines and their use in the prevention of fungal infections. / Dixon, D. M.; Casadevall, Arturo; Klein, B.; Mendoza, L.; Travassos, L.; Deepe, G. S.

In: Medical Mycology, Supplement, Vol. 36, No. 1, 1998, p. 57-67.

Research output: Contribution to journalArticle

Dixon, DM, Casadevall, A, Klein, B, Mendoza, L, Travassos, L & Deepe, GS 1998, 'Development of vaccines and their use in the prevention of fungal infections', Medical Mycology, Supplement, vol. 36, no. 1, pp. 57-67.
Dixon, D. M. ; Casadevall, Arturo ; Klein, B. ; Mendoza, L. ; Travassos, L. ; Deepe, G. S. / Development of vaccines and their use in the prevention of fungal infections. In: Medical Mycology, Supplement. 1998 ; Vol. 36, No. 1. pp. 57-67.
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