Development of scleroderma-like syndrome in Tsk/+ mice is not enhanced by silicone administration

C. Frondoza, Lynne C Jones, N. R. Rose, A. Hatakeyama, R. Phelps, C. Bona

Research output: Contribution to journalArticle

Abstract

The possible role of silicone in the pathogenesis of a scleroderma-like syndrome is still unresolved. It has been proposed that silicone escaping from breast implants potentiates the progression of the disease. To clarify whether silicone enhances development of fibrotic skin lesions and autoantibodies, we tested its effect on tight skin (TSK/+) mice. TSK/+ mice spontaneously develop skin fibrosis and characteristic autoantibodies which resemble human scleroderma. The results of the present study indicate that silicone administratin does not enhance development of skin fibrosis nor synthesis of autoantibodies to RNA polymerase and topoisomerase in TSK/+ mice.

Original languageEnglish (US)
Pages (from-to)299-306
Number of pages8
JournalCurrent Topics in Microbiology and Immunology
Volume210
StatePublished - 1996

Fingerprint

Silicones
Autoantibodies
Skin
Fibrosis
Breast Implants
DNA-Directed RNA Polymerases
Disease Progression

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology and Microbiology(all)
  • Microbiology

Cite this

Development of scleroderma-like syndrome in Tsk/+ mice is not enhanced by silicone administration. / Frondoza, C.; Jones, Lynne C; Rose, N. R.; Hatakeyama, A.; Phelps, R.; Bona, C.

In: Current Topics in Microbiology and Immunology, Vol. 210, 1996, p. 299-306.

Research output: Contribution to journalArticle

Frondoza, C. ; Jones, Lynne C ; Rose, N. R. ; Hatakeyama, A. ; Phelps, R. ; Bona, C. / Development of scleroderma-like syndrome in Tsk/+ mice is not enhanced by silicone administration. In: Current Topics in Microbiology and Immunology. 1996 ; Vol. 210. pp. 299-306.
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