Development of New Strategies for Echinocandins: Progress in Translational Research

Thomas J. Walsh, Nkechi Azie, David R. Andes

Research output: Contribution to journalArticlepeer-review

Abstract

Echinocandins are N-acyl-substituted cyclic hexapeptides with potent in vitro and in vivo activity against Candida species that are used for primary treatment and prevention of candidemia and invasive candidiasis. Recent progress in the translational research of echinocandins has led to new approaches for treatment of central venous catheter Candida biofilms. Other studies have laid the experimental and clinical foundation for use of extended dosing intervals for administration of echinocandins in treatment and prevention of candidemia and invasive candidiasis.

Original languageEnglish (US)
Pages (from-to)S601-S603
JournalClinical Infectious Diseases
Volume61
DOIs
StatePublished - Dec 1 2015

Keywords

  • anidulafungin
  • caspofungin
  • echinocandins
  • micafungin

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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