Development of in vitro fertilization in the United States: a conversation between Zev Rosenwaks and Jairo E. Garcia

Jairo Garcia, Zev Rosenwaks

Research output: Contribution to journalReview articlepeer-review

Abstract

In commemoration of 40 years of in vitro fertilization (IVF), herein we describe the early evolution of the first IVF program at the Eastern Virginia Medical School in Norfolk, Virginia. The birth of the first American IVF baby was the result of the work of many investigators, both in experimental animal models and in humans, heavily relying on the experience of Robert Edwards and Patrick Steptoe in Great Britain. Although their first IVF baby was the result of the retrieval of a single oocyte in the natural cycle, duplicating their methods was not successful in Norfolk. It turns out that the achievement of the first pregnancy in the United States was associated with introducing ovarian stimulation with gonadotropins, establishing the appropriate timing for egg retrieval after hCG administration, retrieving multiple mature oocytes, determining the ideal time for in vitro insemination, and optimizing embryo culture media.

Original languageEnglish (US)
Pages (from-to)14-18
Number of pages5
JournalFertility and Sterility
Volume110
Issue number1
DOIs
StatePublished - Jul 1 2018

Keywords

  • culture media optimization
  • in vitro insemination
  • Ovarian stimulation with gonadotropins for multiple follicle development

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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