Development of functional electron paramagnetic resonance imaging

Murali C. Krishna, Periannan Kuppusamy, Mobae Afeworki, Jay L. Zweier, John A. Cook, Sankaran Subramanian, James B. Mitchell

Research output: Contribution to journalArticle

Abstract

The potential use of electron paramagnetic resonance imaging (EPRI) to obtain physiological information noninvasively is reviewed. EPR, a spectroscopic technique similar to nuclear magnetic resonance (NMR), is useful in detecting and characterizing free radical species. The ability to obtain information about tissue redox and oxygen status using nontoxic free radical spin probes is presented. The capability to encode this information spatially using magnetic field gradients, similar to magnetic resonance imaging (MRI), gives this technique the ability to overlay functional information of tissue with anatomic information. The noninvasive and quantitative nature of EPRI makes it a potentially useful technique for obtaining physiological information from tumors. The requirements for the magnetic field strengths are approximately 600 times lower than that for proton MRI at an identical frequency, making this a low-cost diagnostic tool.

Original languageEnglish (US)
Pages (from-to)209-220
Number of pages12
JournalBreast Disease
Volume10
Issue number3-4
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Surgery

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    Krishna, M. C., Kuppusamy, P., Afeworki, M., Zweier, J. L., Cook, J. A., Subramanian, S., & Mitchell, J. B. (1998). Development of functional electron paramagnetic resonance imaging. Breast Disease, 10(3-4), 209-220.