Development of diagnostic and treatment strategies for glaucoma through understanding and modification of scleral and lamina cribrosa connective tissue

Harry A. Quigley, Frances E. Cone

Research output: Contribution to journalReview article

Abstract

Considerable evidence indicates that the state of ocular connective tissues and their response in glaucomatous disease affect the degree of glaucoma damage. Both experimental and clinical data suggest that improved diagnostic and prognostic information can be derived from the assessment of the mechanical responsiveness of the sclera and lamina cribrosa to intraocular pressure (IOP). Controlled mutagenesis of the sclera has produced a mouse strain that is relatively resistant to increased IOP. Alteration of the baseline scleral state can be accomplished through either increased cross-linking of fibrillar components or their reduction. The sclera is a dynamic structure, altering its structure and behavior in response to IOP change. The biochemical pathways that control these responses are fertile areas for new glaucoma treatments.

Original languageEnglish (US)
Pages (from-to)231-244
Number of pages14
JournalCell and Tissue Research
Volume353
Issue number2
DOIs
StatePublished - Aug 2013

Keywords

  • Glaucoma
  • Pathogenesis
  • Retinal ganglion cell
  • Sclera
  • Therapy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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