Development of comprehensive disease assessment in systemic vasculitis

Oliver Flossmann, Paul Bacon, Kirsten De Groot, David Jayne, Niels Rasmussen, Philip Seo, Kerstin Westman, Raashid Luqmani

Research output: Contribution to journalReview articlepeer-review

Abstract

The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This article reviews and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis and reports ongoing initiatives for further development of disease assessment tools. A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and prognosis. The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic irreversible damage and impairment of function.

Original languageEnglish (US)
Pages (from-to)283-292
Number of pages10
JournalAnnals of the rheumatic diseases
Volume66
Issue number3
DOIs
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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