TY - JOUR
T1 - Development of Common Data Elements for Use in Chiari Malformation Type i Clinical Research
T2 - An NIH/NINDS Project
AU - Luciano, Mark G.
AU - Batzdorf, Ulrich
AU - Kula, Roger W.
AU - Rocque, Brandon G.
AU - Maher, Cormac O.
AU - Heiss, John
AU - Martin, Bryn A.
AU - Bolognese, Paolo A.
AU - Ashley-Koch, Allison
AU - Limbrick, David
AU - Poppe, Dorothy J.
AU - Esposito, Kaitlyn M.
AU - Odenkirchen, Joanne
AU - Esterlitz, Joy R.
AU - Ala'i, Sherita
AU - Joseph, Kristen
AU - Feldman, Robin S.
AU - Riddle, Robert
N1 - Publisher Copyright:
© 2019 by the Congress of Neurological Surgeons.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - The management of Chiari I malformation (CMI) is controversial because treatment methods vary and treatment decisions rest on incomplete understanding of its complex symptom patterns, etiologies, and natural history. Validity of studies that attempt to compare treatment of CMI has been limited because of variable terminology and methods used to describe study subjects. The goal of this project was to standardize terminology and methods by developing a comprehensive set of Common Data Elements (CDEs), data definitions, case report forms (CRFs), and outcome measure recommendations for use in CMI clinical research, as part of the CDE project at the National Institute of Neurological Disorders and Stroke (NINDS) of the US National Institutes of Health. A working group, comprising over 30 experts, developed and identified CDEs, template CRFs, data dictionaries, and guidelines to aid investigators starting and conducting CMI clinical research studies. The recommendations were compiled, internally reviewed, and posted online for external public comment. In October 2016, version 1.0 of the CMI CDE recommendations became available on the NINDS CDE website. The recommendations span these domains: Core Demographics/Epidemiology; Presentation/Symptoms; Co-Morbidities/Genetics; Imaging; Treatment; and Outcome. Widespread use of CDEs could facilitate CMI clinical research trial design, data sharing, retrospective analyses, and consistent data sharing between CMI investigators around the world. Updating of CDEs will be necessary to keep them relevant and applicable to evolving research goals for understanding CMI and its treatment.
AB - The management of Chiari I malformation (CMI) is controversial because treatment methods vary and treatment decisions rest on incomplete understanding of its complex symptom patterns, etiologies, and natural history. Validity of studies that attempt to compare treatment of CMI has been limited because of variable terminology and methods used to describe study subjects. The goal of this project was to standardize terminology and methods by developing a comprehensive set of Common Data Elements (CDEs), data definitions, case report forms (CRFs), and outcome measure recommendations for use in CMI clinical research, as part of the CDE project at the National Institute of Neurological Disorders and Stroke (NINDS) of the US National Institutes of Health. A working group, comprising over 30 experts, developed and identified CDEs, template CRFs, data dictionaries, and guidelines to aid investigators starting and conducting CMI clinical research studies. The recommendations were compiled, internally reviewed, and posted online for external public comment. In October 2016, version 1.0 of the CMI CDE recommendations became available on the NINDS CDE website. The recommendations span these domains: Core Demographics/Epidemiology; Presentation/Symptoms; Co-Morbidities/Genetics; Imaging; Treatment; and Outcome. Widespread use of CDEs could facilitate CMI clinical research trial design, data sharing, retrospective analyses, and consistent data sharing between CMI investigators around the world. Updating of CDEs will be necessary to keep them relevant and applicable to evolving research goals for understanding CMI and its treatment.
KW - Chiari Malformation
KW - Common Data Elements
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U2 - 10.1093/neuros/nyy475
DO - 10.1093/neuros/nyy475
M3 - Article
C2 - 30690581
AN - SCOPUS:85074612848
SN - 0148-396X
VL - 85
SP - 854
EP - 859
JO - Clinical Neurosurgery
JF - Clinical Neurosurgery
IS - 6
ER -