Development of central neurotransmitter‐specified neuronal systems: Implications for pediatric neuro‐psychiatric disorders

J. T. Coyle, H. Singer, M. Beaulieu, M. V. Johnston

Research output: Contribution to journalReview articlepeer-review

Abstract

Abstract– An increasing focus on the mechanism of synaptic neuro‐chemistry in pediatric neurology, may lead to a better understanding of the pathophysiology of many disorders and result in a more rational approach to their pharmacotherapy. With the burgeoning list of putative neurotrans‐mitters in brain, and the growing evidence of co‐localization of many of these neurotransmitters, chemical neurotransmission likely involves a higher degree of complexity than appreciated heretofore. The potential role of neurotransmitter dysfunction in the pathophysiology of neurologic and behavior disorders of children, should not be considered as restricted to those disorders that involve selective neuronal loss, but may encompass a much wider spectrum of syndromes due to metabolic abnormalities, as well as disturbances of the finer features of chemical neurotransmission.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalActa Neurologica Scandinavica
Volume70
Issue number1
DOIs
StatePublished - Jul 1984

Keywords

  • Tourette's syndrome
  • gangliosidosis
  • methylazoxymethanol
  • neurotransmitters
  • norepine‐phrine
  • γ‐Amino butyric acid

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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