Development of battery-free neural interface and modulated control of tibialis anterior muscle via common peroneal nerve based on triboelectric nanogenerators (TENGs)

Sanghoon Lee, Hao Wang, Qiongfeng Shi, Lokesh Dhakar, Jiahui Wang, Nitish V Thakor, Shih Cheng Yen, Chengkuo Lee

Research output: Contribution to journalArticle

Abstract

Flexible and stretchable electronics, also known as e-skin, have been a technology to create diversified sensors and wearable devices. Implantable bioelectronics have recently been recognized as a promising research field to modulate biological signals and treat many diseases and pathological conditions. The marriage of two technologies gives us a new cutting-edge research area, i.e., implantable flexible electronics. While strain sensors, ECG sensors, pH sensors, temperature sensors and LED chips have been integrated together as a novel platform for measuring physiological signals, one of critical challenges for long-term use of such devices is a reliable power source with sound output power. To support operation of the implantable bioelectronics, triboelectric nanogenerators (TENGs) have recently been explored, as a promising technology to harvest energy, as the concept of scavenging human body energy into useful electrical power. In this work, we investigate stacked TENGs with output voltage of 160 Vp-p and a short circuit current of 6.7 µA as a potential power source for neural stimulation using flexible and adjustable neural interfaces. To advance a generic design of flexible neural interfaces which is good at sciatic nerve recording and stimulation, we optimize a new flexible sling electrode and successfully achieve neural signal recording with different amplitudes and latencies. More importantly, successful selective stimulation achieved in this work proves that the flexible sling electrode is a good generic neural interface. We demonstrate direct stimulation of a sciatic nerve and a common peroneal nerve in rats by the TENGs connected with the suggested interface and a pair of Pt/Ir wires, respectively, while monitoring muscle signals. The muscle contraction can be controlled by the operation of the TENGs. This prove-concept result indicates that this technology could be the way of realizing battery-free wearable neuromodulators in the future.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalNano Energy
Volume33
DOIs
StatePublished - Mar 1 2017

Keywords

  • e-Skin
  • Flexible electronics
  • Implantable bioelectronics
  • Neural interface
  • Selective stimulation
  • Triboelectric nanogenerator (TENG)

ASJC Scopus subject areas

  • Renewable Energy, Sustainability and the Environment
  • Materials Science(all)
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Development of battery-free neural interface and modulated control of tibialis anterior muscle via common peroneal nerve based on triboelectric nanogenerators (TENGs)'. Together they form a unique fingerprint.

  • Cite this