Development of amino acid receptors in frontal cortex from girls with Rett syndrome

Research output: Contribution to journalArticle

Abstract

To determine whether a disorder of excitatory neuro-transmission plays a role in the pathophysiology of Rett syndrome (RS), N-methyl-D-aspartate (NMDA), adenosine monophosphate acid (AMPA), kainate, and metabotropic types of glutamate receptors were labeled autoradiographically in the superior frontal gyrus (SFG) from 9 RS patients and 10 female controls. The results showed a trend for the densities of NMDA, AMPA, gamma-aminobutyric acid, and metabotropic glutamate receptors to be higher in younger patients than in controls and for densities in older patients to fall below those of controls. The age-related changes in SFG NMDA receptor density may be correlated with the shift from psychomotor regression and seizures in younger stage II/III RS girls to the less epileptic plateau stage in older girls.

Original languageEnglish (US)
Pages (from-to)541-545
Number of pages5
JournalAnnals of neurology
Volume45
Issue number4
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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