Development of age-dependent resistance to sindbis virus encephalitis: Correlation with inactivation of virus within the blood stream

Robert L. Hirsch, Diane E. Griffin

Research output: Contribution to journalArticle

Abstract

The clearance of Sindbis virus from the blood stream and its localization in the reticuloendothelial system (RES) was studied in mice susceptible (2 weeks old) and resistant (6 weeks old) to fatal Sindbis virus encephalitis. No significant differences in the relative capacity of 2-week-old and 6-week-old mice to remove 125I-labeled virus from the blood stream and to localize virus within the liver were observed. However, the decline of infectious virus was more rapid in the blood of adult mice. These studies suggest that, in addition to physical removal of virus by the RES, inactivation of virus in the blood stream plays an important role in limiting viremia during infections with Sindbis virus.

Original languageEnglish (US)
Pages (from-to)263-267
Number of pages5
JournalAntiviral Research
Volume1
Issue number4
DOIs
StatePublished - Nov 1981

Keywords

  • Sindbis virus
  • age-dependent resistance
  • non-specific resistance
  • reticuloendothelial cell system

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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