Development of a simplified isotopic antiglobulin assay for the study of tumor-specific antibody

James F. Burdick, Samuel A. Wells, Alfred M. Cohen, Alfred S. Ketcham

Research output: Contribution to journalArticlepeer-review

Abstract

An adaption of the indirect isotopic antiglobulin test is described for use on a micro scale with cell monolayers. The ease of washing greatly simplifies the technique. Antibody against the tumor-specific surface antigens on a carcinogen-induced murine sarcoma is detected with high sensitivity. Antibody is detectable against the tumor in the serum of animals which have that tumor actively growing. Four of the eight MCA-induced tumors studied have a common cell-surface antigen.

Original languageEnglish (US)
Pages (from-to)200-206
Number of pages7
JournalJournal of Surgical Research
Volume14
Issue number3
DOIs
StatePublished - Mar 1973
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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