Development of a multi-modal sensor for in vivo monitoring of tumor oxygen dynamics

Bo Qiang, Xianhua Cao, Duxin Sun, Guanglong He, Jay Zweier, Ronald Xu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A multi-modal sensor has been developed for non-invasive, real time, in vivo monitoring of oxygen intake, consumption and blood flow dynamics in tumor tissue during ischemia-reperfusion. The sensor head integrated a near infrared tissue oximeter for tissue oxygen saturation and hemoglobin concentration measurement, a laser Doppler for blood flow measurement, and an electron paramagnetic resonance spectroscope (EPRS) for oxygen tension measurement. The sensor has been tested on athymic NU/NU mice with xenograft pancreatic cancer implanted on right legs. Ischemia-reperfusion was introduced by physical ligation of the femur artery. Preliminary results demonstrated technical feasibility of simultaneous tissue oxygen and blood flow measurements. Further data analysis is on the way.

Original languageEnglish (US)
Title of host publicationIRMMW-THz 2006 - 31st International Conference on Infrared and Millimeter Waves and 14th International Conference on Terahertz Electronics
Pages249
Number of pages1
DOIs
Publication statusPublished - 2006
Externally publishedYes
EventIRMMW-THz 2006 - 31st International Conference on Infrared and Millimeter Waves and 14th International Conference on Terahertz Electronics - Shanghai, China
Duration: Sep 18 2006Sep 22 2006

Other

OtherIRMMW-THz 2006 - 31st International Conference on Infrared and Millimeter Waves and 14th International Conference on Terahertz Electronics
CountryChina
CityShanghai
Period9/18/069/22/06

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ASJC Scopus subject areas

  • Computer Networks and Communications
  • Electrical and Electronic Engineering

Cite this

Qiang, B., Cao, X., Sun, D., He, G., Zweier, J., & Xu, R. (2006). Development of a multi-modal sensor for in vivo monitoring of tumor oxygen dynamics. In IRMMW-THz 2006 - 31st International Conference on Infrared and Millimeter Waves and 14th International Conference on Terahertz Electronics (pp. 249). [4222191] https://doi.org/10.1109/ICIMW.2006.368457