Development of a monoclonal antibody against a tumor-associated antigen

W. W. Peng; J. P. Bressler; E. Tiffany-Castiglioni; J. De Vellis

doi:10.1126/science.7063842

Development of a monoclonal antibody against a tumor-associated antigen

W. W. Peng, J. P. Bressler, E. Tiffany-Castiglioni, J. De Vellis

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Abstract

A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.

Original language	English (US)
Pages (from-to)	1102-1104
Number of pages	3
Journal	Science
Volume	215
Issue number	4536
DOIs	https://doi.org/10.1126/science.7063842
State	Published - 1982
Externally published	Yes

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title = "Development of a monoclonal antibody against a tumor-associated antigen",

abstract = "A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.",

author = "Peng, {W. W.} and Bressler, {J. P.} and E. Tiffany-Castiglioni and {De Vellis}, J.",

year = "1982",

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AU - Peng, W. W.

AU - Bressler, J. P.

AU - Tiffany-Castiglioni, E.

AU - De Vellis, J.

PY - 1982

Y1 - 1982

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AB - A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.

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Development of a monoclonal antibody against a tumor-associated antigen

Abstract

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