Development of a monoclonal antibody against a tumor-associated antigen

W. W. Peng, Joseph Bressler, E. Tiffany-Castiglioni, J. De Vellis

Research output: Contribution to journalArticle

Abstract

A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.

Original languageEnglish (US)
Pages (from-to)1102-1104
Number of pages3
JournalScience
Volume215
Issue number4536
StatePublished - 1982
Externally publishedYes

Fingerprint

Neoplasm Antigens
Oligodendroglia
Monoclonal Antibodies
Glioma
Cell Line
Astrocytes
Antibody-Producing Cells
Hybrid Cells
Surface Antigens
Neuroglia
Spleen
Fibroblasts
Antigens
Antibodies
Brain
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Peng, W. W., Bressler, J., Tiffany-Castiglioni, E., & De Vellis, J. (1982). Development of a monoclonal antibody against a tumor-associated antigen. Science, 215(4536), 1102-1104.

Development of a monoclonal antibody against a tumor-associated antigen. / Peng, W. W.; Bressler, Joseph; Tiffany-Castiglioni, E.; De Vellis, J.

In: Science, Vol. 215, No. 4536, 1982, p. 1102-1104.

Research output: Contribution to journalArticle

Peng, WW, Bressler, J, Tiffany-Castiglioni, E & De Vellis, J 1982, 'Development of a monoclonal antibody against a tumor-associated antigen', Science, vol. 215, no. 4536, pp. 1102-1104.
Peng WW, Bressler J, Tiffany-Castiglioni E, De Vellis J. Development of a monoclonal antibody against a tumor-associated antigen. Science. 1982;215(4536):1102-1104.
Peng, W. W. ; Bressler, Joseph ; Tiffany-Castiglioni, E. ; De Vellis, J. / Development of a monoclonal antibody against a tumor-associated antigen. In: Science. 1982 ; Vol. 215, No. 4536. pp. 1102-1104.
@article{a695e26f5a754154a2ef8d8239f69b54,
title = "Development of a monoclonal antibody against a tumor-associated antigen",
abstract = "A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.",
author = "Peng, {W. W.} and Joseph Bressler and E. Tiffany-Castiglioni and {De Vellis}, J.",
year = "1982",
language = "English (US)",
volume = "215",
pages = "1102--1104",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4536",

}

TY - JOUR

T1 - Development of a monoclonal antibody against a tumor-associated antigen

AU - Peng, W. W.

AU - Bressler, Joseph

AU - Tiffany-Castiglioni, E.

AU - De Vellis, J.

PY - 1982

Y1 - 1982

N2 - A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.

AB - A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.

UR - http://www.scopus.com/inward/record.url?scp=0020037437&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020037437&partnerID=8YFLogxK

M3 - Article

C2 - 7063842

AN - SCOPUS:0020037437

VL - 215

SP - 1102

EP - 1104

JO - Science

JF - Science

SN - 0036-8075

IS - 4536

ER -