Development of a monoclonal antibody against a tumor-associated antigen

W. W. Peng, J. P. Bressler, E. Tiffany-Castiglioni, J. De Vellis

Research output: Contribution to journalArticle

Abstract

A monoclonal antibody-producing hybrid cell line was obtained by fusing mouse myeloma cells with spleen cells from a mouse immunized with C6 glioma cells. This antibody binds to a specific cell-surface antigen that is present on C6 rat glioma cells, transformed astrocytes and oligodendrocytes, and a human glioma cell line but is absent on a normal glial cell line, fibroblasts, and primary cultures of astrocytes and oligodendrocytes. The antigen also appears on tumor tissue of transformed oligodendrocytes but not on normal brain tissue.

Original languageEnglish (US)
Pages (from-to)1102-1104
Number of pages3
JournalScience
Volume215
Issue number4536
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

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