Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9

Larry H. Yamaoka, Carol A. Westbrook, Marcy C. Speer, James M. Gilchrist, Ethylin W. Jabs, Elizabeth G. Schweins, Jeffrey M. Stajich, Perry C. Gaskell, Allen D. Roses, Margaret A. Pericak-Vance

Research output: Contribution to journalArticle

Abstract

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000 : 1.

Original languageEnglish (US)
Pages (from-to)471-475
Number of pages5
JournalNeuromuscular Disorders
Volume4
Issue number5-6
DOIs
StatePublished - 1994

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ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Yamaoka, L. H., Westbrook, C. A., Speer, M. C., Gilchrist, J. M., Jabs, E. W., Schweins, E. G., Stajich, J. M., Gaskell, P. C., Roses, A. D., & Pericak-Vance, M. A. (1994). Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9. Neuromuscular Disorders, 4(5-6), 471-475. https://doi.org/10.1016/0960-8966(94)90086-8