Development of a Metastatic Spinal Tumor Frailty Index (MSTFI) Using a Nationwide Database and Its Association with Inpatient Morbidity, Mortality, and Length of Stay After Spine Surgery

Rafael De la Garza Ramos, C. Rory Goodwin, Amit Jain, Nancy Abu-Bonsrah, Charles G. Fisher, Chetan Bettegowda, Daniel M. Sciubba

Research output: Contribution to journalArticlepeer-review

Abstract

Objective The aim of this study was to develop a perioperative metastatic spinal tumor frailty index (MSTFI) that could predict morbidity, mortality, and length of stay. Methods A large inpatient hospitalization database was searched from 2002 to 2011 to identify 4583 patients with spinal metastasis from breast (21.1%), lung (34.1%), thyroid (3.8%), renal (19.9%), and prostate (21.1%) cancer who underwent surgery. A multiple logistic regression model identified 9 independent parameters that were used to construct the MSTFI: anemia, chronic lung disease, coagulopathy, electrolyte abnormalities, pulmonary circulation disorders, renal failure, malnutrition, emergent/urgent admission, and anterior/combined surgical approach. Patients with 0 points were categorized as “not frail,” 1 as “mildly frail,” 2 as “moderately frail,” and ≥3 as “severely frail.” Results The overall perioperative complication rate was 19.3% and in-patient mortality was 3.0%. Compared with patients with no frailty, patients with moderate frailty (odds ratio [OR] 5.15; 95% confidence interval [95% CI] 2.44–10.86), and severe frailty (OR 5.74; 95% CI 2.69–12.24) had significantly increased odds of inpatient mortality (all P < 0.001). Similarly, patients with mild frailty (OR 1.88; 95% CI 1.33–2.66), moderate frailty (OR 3.83; 95% CI 2.71–5.41), and severe frailty (OR 6.97; 95% CI 4.98–9.74) had significantly increased odds of developing a major in-hospital complication (all P < 0.001). Length of stay also increased significantly by MSTFI (P < 0.001). Conclusions In surgically treated patients with spinal metastasis, certain perioperative parameters may significantly predict the risk of major in-hospital complications and mortality.

Original languageEnglish (US)
Pages (from-to)548-555.e4
JournalWorld neurosurgery
Volume95
DOIs
StatePublished - Nov 1 2016

Keywords

  • Cancer
  • Frailty
  • Frailty index
  • Metastasis
  • Spinal metastatic tumor
  • Spine surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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