A finite element model (FEM) of the human head attached to a Hybrid III FEM neck was developed to study the effects of blast loading on the brain. Simulations of blast loading to this Human Head Finite Element Model (HHFEM) were generated by creating a computational fluid dynamics (CFD) model of the HHFEM headform in a shock tube. Three different driver pressure loading conditions from experimental testing of the Human Surrogate Head Model (HSHM) were simulated by this model. The pressure time histories at each grid point of the CFD headform were used as inputs to the HHFEM. Brain/cerebral spinal fluid (CSF) and CSF/skull boundary conditions along with different brain material models were considered. The Kelvin-Maxwell material model and a low friction surface-to-surface interface were found to best replicate conditions seen in experimental testing of the HSHM. Deformations in the anterior and posterior locations of the brain varied from 0.5-0.9 mm and intracranial pressures at those locations were between 32 and 55 kPa.