TY - JOUR
T1 - Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses
AU - VISTA Steering Committees
AU - Ali, Myzoon
AU - Bath, Philip
AU - Brady, Marian
AU - Davis, Stephen
AU - Diener, Hans Christoph
AU - Donnan, Geoffrey
AU - Fisher, Marc
AU - Hacke, Werner
AU - Hanley, Daniel F.
AU - Luby, Marie
AU - Tsivgoulis, G.
AU - Wahlgren, Nils
AU - Steven Warach, Steven
AU - Lees, Kennedy R.
AU - Alexandrov, A.
AU - Bath, P. W.
AU - Bluhmki, E.
AU - Claesson, L.
AU - Davis, S. M.
AU - Gregson, B.
AU - Grotta, J.
AU - Hennerici, M. G.
AU - Hommel, M.
AU - Kaste, M.
AU - Lyden, P.
AU - Marler, J.
AU - Muir, K.
AU - Sacco, R.
AU - Shuaib, A.
AU - Teal, P.
AU - Wahlgren, N. G.
AU - Warach, S.
AU - Weimar, C.
AU - Ashburn, A.
AU - Barer, D.
AU - Bowen, A.
AU - Brodie, E.
AU - Corr, S.
AU - Drummond, A.
AU - Edmans, J.
AU - English, C.
AU - Gladman, J.
AU - Kalra, L.
AU - Langhorne, P.
AU - Lincoln, N.
AU - Logan, P.
AU - Mead, G.
AU - Patchick, E.
AU - Pollock, A.
AU - Pomeroy, V.
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Introduction: Analysis of reliable registry data can direct future research to influence clinical care. Data from the Virtual International Stroke Trials Archive have been used to test hypotheses and inform trial design. We sought to expand Virtual International Stroke Trials Archive into a broader stroke resource with new opportunities for research and international collaboration. Methods: Using procedures initially developed for an acute stroke trial archive, we invited trialists to lodge data on rehabilitation, secondary prevention, intracerebral haemorrhage, imaging, and observational stroke studies. Results: We have extended Virtual International Stroke Trials Archive into six subsections: Virtual International Stroke Trials Archive-Acute (n=28190 patients' data), Virtual International Stroke Trials Archive-Rehab (n=10194), Virtual International Stroke Trials Archive-intracerebral haemorrhage (n=1829), Virtual International Stroke Trials Archive-Prevention, Virtual International Stroke Trials Archive-Imaging (n=1300), and Virtual International Stroke Trials Archive-Plus (n=6573). Enrollment continues, with commitments for the contribution of six further trials to Virtual International Stroke Trials Archive-Prevention, 13 trials to Virtual International Stroke Trials Archive-Rehab, and one registry to Virtual International Stroke Trials Archive-Plus. Data on age, type of stroke, medical history, outcomes by modified Rankin scale and Barthel Index (BI), mortality, and adverse events are available for analyses. The Virtual International Stroke Trials Archive network encourages the development of young investigators and provides opportunities for international peer review and collaboration. Conclusions: Application of the original Virtual International Stroke Trials Archive concepts beyond acute stroke trials can extend the value of clinical research at low cost, without threatening commercial or intellectual property interests. This delivers valuable research output to inform the efficiency of future stroke research. We invite stroke researchers to participate actively in Virtual International Stroke Trials Archive and encourage the extension of Virtual International Stroke Trials Archive principles to other disease areas.
AB - Introduction: Analysis of reliable registry data can direct future research to influence clinical care. Data from the Virtual International Stroke Trials Archive have been used to test hypotheses and inform trial design. We sought to expand Virtual International Stroke Trials Archive into a broader stroke resource with new opportunities for research and international collaboration. Methods: Using procedures initially developed for an acute stroke trial archive, we invited trialists to lodge data on rehabilitation, secondary prevention, intracerebral haemorrhage, imaging, and observational stroke studies. Results: We have extended Virtual International Stroke Trials Archive into six subsections: Virtual International Stroke Trials Archive-Acute (n=28190 patients' data), Virtual International Stroke Trials Archive-Rehab (n=10194), Virtual International Stroke Trials Archive-intracerebral haemorrhage (n=1829), Virtual International Stroke Trials Archive-Prevention, Virtual International Stroke Trials Archive-Imaging (n=1300), and Virtual International Stroke Trials Archive-Plus (n=6573). Enrollment continues, with commitments for the contribution of six further trials to Virtual International Stroke Trials Archive-Prevention, 13 trials to Virtual International Stroke Trials Archive-Rehab, and one registry to Virtual International Stroke Trials Archive-Plus. Data on age, type of stroke, medical history, outcomes by modified Rankin scale and Barthel Index (BI), mortality, and adverse events are available for analyses. The Virtual International Stroke Trials Archive network encourages the development of young investigators and provides opportunities for international peer review and collaboration. Conclusions: Application of the original Virtual International Stroke Trials Archive concepts beyond acute stroke trials can extend the value of clinical research at low cost, without threatening commercial or intellectual property interests. This delivers valuable research output to inform the efficiency of future stroke research. We invite stroke researchers to participate actively in Virtual International Stroke Trials Archive and encourage the extension of Virtual International Stroke Trials Archive principles to other disease areas.
KW - Database
KW - Secondary analysis
KW - Stroke
KW - Trial design
UR - http://www.scopus.com/inward/record.url?scp=84856145783&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856145783&partnerID=8YFLogxK
U2 - 10.1111/j.1747-4949.2011.00735.x
DO - 10.1111/j.1747-4949.2011.00735.x
M3 - Article
C2 - 22264365
AN - SCOPUS:84856145783
SN - 1747-4930
VL - 7
SP - 133
EP - 138
JO - International Journal of Stroke
JF - International Journal of Stroke
IS - 2
ER -