Development and validation of a quality-of-life questionnaire for mechanically ventilated ICU patients

Research output: Contribution to journalArticle

Abstract

Objective: To develop and validate a new instrument for measuring health-related quality of life in mechanically ventilated patients in the ICU. Design: Expert panel consensus and a prospective longitudinal survey. Setting: Urban, academic, tertiary care medical center. Patients: One hundred fifteen awake, mechanically ventilated, ICU patients who either received a tracheostomy or remained endotracheally intubated. Interventions: A new quality-of-life instrument was developed and validated by using pilot study data; informal interviews of patients, families, and nurses; expert panel consensus; and item analyses. The new instrument was used to measure quality of life at three time points (5 d, 10 d, and 15 d after intubation). Measurements and Main Results: A new 12-item quality-of-life questionnaire for mechanically ventilated patients was developed. Patients' responses to the quality-of-life questionnaire revealed moderate-to-high correlations with EuroQol scores (r = -0.4 to -0.9) and the EuroQol Visual Analog Scale (r = 0.6-0.9) across the three times and a moderate correlation with the Sequential Organ Failure Assessment tool (r = 0.5) at 10 days after intubation. Cronbach α ranged from 0.80 to 0.94 across the three times. The quality-of-life questionnaire for mechanically ventilated patients was responsive to changes in treatment modalities (tracheostomy vs no tracheostomy and early vs late tracheostomy demarcated by 10 d of intubation). Exploratory factor analysis revealed that this instrument was unidimensional in nature. Conclusions: The new quality-of-life questionnaire for mechanically ventilated patients is valid and can reliably measure quality of life in mechanically ventilated ICU patients. It may provide clinicians with an accurate assessment of patients' quality of life and facilitate optimal decision making regarding patients' ICU plan of care.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalCritical care medicine
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Instrument
  • Mechanically ventilated
  • Quality of life
  • Reliability
  • Tracheostomy
  • Validity

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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