Abstract
T-cell receptor transgenic mice are powerful tools to study T cell responses to malaria parasites. They allow for a population of antigen specific T cells to be monitored during developing responses to immunization or parasite infection; this makes them particularly useful to study fundamental aspects of T cell activation, differentiation, and migration in different tissue compartments. Moreover, the use of these cells allows for a thorough analysis of the mechanisms of antiparasite activity by T cells.
Original language | English (US) |
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Pages (from-to) | 481-491 |
Number of pages | 11 |
Journal | Methods in molecular biology (Clifton, N.J.) |
Volume | 923 |
State | Published - 2013 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine