Development and use of TCR transgenic mice for malaria immunology research.

Yun Chi Chen, Fidel Zavala

Research output: Contribution to journalArticlepeer-review

Abstract

T-cell receptor transgenic mice are powerful tools to study T cell responses to malaria parasites. They allow for a population of antigen specific T cells to be monitored during developing responses to immunization or parasite infection; this makes them particularly useful to study fundamental aspects of T cell activation, differentiation, and migration in different tissue compartments. Moreover, the use of these cells allows for a thorough analysis of the mechanisms of antiparasite activity by T cells.

Original languageEnglish (US)
Pages (from-to)481-491
Number of pages11
JournalMethods in molecular biology (Clifton, N.J.)
Volume923
StatePublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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