Development and use of TCR transgenic mice for malaria immunology research

Yun Chi Chen, Fidel Zavala

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

T-cell receptor transgenic mice are powerful tools to study T cell responses to malaria parasites. They allow for a population of antigen specific T cells to be monitored during developing responses to immunization or parasite infection; this makes them particularly useful to study fundamental aspects of T cell activation, differentiation, and migration in different tissue compartments. Moreover, the use of these cells allows for a thorough analysis of the mechanisms of antiparasite activity by T cells.

Original languageEnglish (US)
Title of host publicationMalaria
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages481-491
Number of pages11
ISBN (Print)9781627030250
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume923
ISSN (Print)1064-3745

Keywords

  • Plasmodium blood stages
  • Plasmodium liver stages
  • T cells
  • TCR transgenic mice

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint

Dive into the research topics of 'Development and use of TCR transgenic mice for malaria immunology research'. Together they form a unique fingerprint.

Cite this