Development and implementation of a high-performance, cardiac-gated dual-energy imaging system

N. A. Shkuma, Jeff Siewerdsen, A. C. Dhanantwari, D. B. Williams, S. Richard, D. J. Tward, N. S. Paul, J. Yorkston, R. Van Metter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mounting evidence suggests that the superposition of anatomical clutter in a projection radiograph poses a major impediment to the detectability of subtle lung nodules. Through decomposition of projections acquired at multiple kVp, dual-energy (DE) imaging offers to dramatically improve lung nodule detectability and, in part through quantitation of nodule calcification, increase specificity in nodule characterization. The development of a high-performance DE chest imaging system is reported, with design and implementation guided by fundamental imaging performance metrics. A diagnostic chest stand (Kodak RVG 5100 digital radiography system) provided the basic platform, modified to include: (i) a filter wheel, (ii) a flat-panel detector (Trixell Pixium 4600), (iii) a computer control and monitoring system for cardiac-gated acquisition, and (iv) DE image decomposition and display. Computational and experimental studies of imaging performance guided optimization of key acquisition technique parameters, including: x-ray filtration, allocation of dose between low- and high-energy projections, and kVp selection. A system for cardiac-gated acquisition was developed, directing x-ray exposures to within the quiescent period of the heart cycle, thereby minimizing anatomical misregistration. A research protocol including 200 patients imaged following lung nodule biopsy is underway, allowing preclinical evaluation of DE imaging performance relative to conventional radiography and low-dose CT.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6510
EditionPART 1
DOIs
StatePublished - 2007
Externally publishedYes
EventMedical Imaging 2007: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2007Feb 22 2007

Other

OtherMedical Imaging 2007: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/18/072/22/07

Fingerprint

Imaging systems
Imaging techniques
Radiography
Decomposition
X rays
Biopsy
Computer control
Mountings
Dosimetry
Wheels
Display devices
Detectors
Monitoring

Keywords

  • Cardiac gating
  • Dual-energy imaging
  • Flat-panel detector
  • Image acquisition technique
  • Image quality
  • Imaging dose
  • Imaging performance
  • Lung cancer
  • Optimization
  • Thoracic imaging

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Shkuma, N. A., Siewerdsen, J., Dhanantwari, A. C., Williams, D. B., Richard, S., Tward, D. J., ... Van Metter, R. (2007). Development and implementation of a high-performance, cardiac-gated dual-energy imaging system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (PART 1 ed., Vol. 6510). [651006] https://doi.org/10.1117/12.713680

Development and implementation of a high-performance, cardiac-gated dual-energy imaging system. / Shkuma, N. A.; Siewerdsen, Jeff; Dhanantwari, A. C.; Williams, D. B.; Richard, S.; Tward, D. J.; Paul, N. S.; Yorkston, J.; Van Metter, R.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6510 PART 1. ed. 2007. 651006.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shkuma, NA, Siewerdsen, J, Dhanantwari, AC, Williams, DB, Richard, S, Tward, DJ, Paul, NS, Yorkston, J & Van Metter, R 2007, Development and implementation of a high-performance, cardiac-gated dual-energy imaging system. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 1 edn, vol. 6510, 651006, Medical Imaging 2007: Physics of Medical Imaging, San Diego, CA, United States, 2/18/07. https://doi.org/10.1117/12.713680
Shkuma NA, Siewerdsen J, Dhanantwari AC, Williams DB, Richard S, Tward DJ et al. Development and implementation of a high-performance, cardiac-gated dual-energy imaging system. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. PART 1 ed. Vol. 6510. 2007. 651006 https://doi.org/10.1117/12.713680
Shkuma, N. A. ; Siewerdsen, Jeff ; Dhanantwari, A. C. ; Williams, D. B. ; Richard, S. ; Tward, D. J. ; Paul, N. S. ; Yorkston, J. ; Van Metter, R. / Development and implementation of a high-performance, cardiac-gated dual-energy imaging system. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6510 PART 1. ed. 2007.
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