Development and Impact of de Novo Anti-HLA Antibodies in Pediatric Heart Transplant Recipients

C. K. Chen, Cedric Manlhiot, J. Conway, T. Allain-Rooney, B. W. McCrindle, K. Tinckam, A. I. Dipchand

Research output: Contribution to journalArticle

Abstract

There is increasing evidence that de novo anti-HLA antibodies, more specifically de novo donor-specific antibodies (DSA) following solid organ transplantation may be associated with negative outcomes including rejection in the first year and graft loss. Limited data are available in pediatric heart transplant recipients. We sought to prospectively determine the incidence, class and early impact of de novo anti-HLA antibodies in a cohort of pediatric heart transplant recipients. Serial panel reactive antibody testing posttransplant was performed in 25 patients (14 males) transplanted between January 2008 and June 2010. Five patients were sensitized pretransplant; all patients had negative direct crossmatch. Seventy-two percent developed de novo anti-HLA antibodies at a median of 2.6 weeks (IQR 1.2 weeks to 6.2 months) posttransplant; 67% of these were DSA. The majority of recipients in our cohort developed de novo anti-HLA antibodies within the first year posttransplant, with two-thirds being donor-specific. Acute cellular rejection, though frequent, was not different in patients with antibody development regardless of class or specificity, and there was no antibody-mediated rejection, graft loss or early cardiac allograft vasculopathy.

Original languageEnglish (US)
Pages (from-to)2215-2222
Number of pages8
JournalAmerican Journal of Transplantation
Volume15
Issue number8
DOIs
Publication statusPublished - Aug 1 2015
Externally publishedYes

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Keywords

  • alloantibody
  • clinical research / practice
  • heart transplantation / cardiology
  • panel reactive antibody (PRA)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Chen, C. K., Manlhiot, C., Conway, J., Allain-Rooney, T., McCrindle, B. W., Tinckam, K., & Dipchand, A. I. (2015). Development and Impact of de Novo Anti-HLA Antibodies in Pediatric Heart Transplant Recipients. American Journal of Transplantation, 15(8), 2215-2222. https://doi.org/10.1111/ajt.13259