Development and evaluation of copper-67 and samarium-153 labeled conjugates for tumor radioimmunotherapy

S. C. Srivastava, L. F. Mausner, R. C. Mease, G. E. Meinken, V. Joshi, K. Kolsky, M. Sweet, Z. Steplewski

Research output: Contribution to journalArticle

Abstract

Copper-67 and samarium-153 are two of the most attractive radionuclides for radioimmunotherapy. Two to three-day half-lives, intermediate-energy beta emissions, imageable photons, and suitable chemical characteristics make these radionuclides ideal for this application. Work on the production of high specific activity 67Cu and 153Sm, as well as the development of stable chelates for conjugating these radiometals to tumor-associated monoclonal antibodies is presented. Based on preliminary in vitro and in vivo studies (in nude mice xenografted with human colon carcinoma), both 67Cu and 153Sm appear very promising for tumor radioimmunotherapy and warrant continued investigation.

Original languageEnglish (US)
Pages (from-to)92-101
Number of pages10
JournalInternational Journal of Pharmacognosy
Volume33
Issue numberSUPPL.
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Antibodies
  • Copper-67
  • Radioimmunotherapy
  • Samarium-153

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'Development and evaluation of copper-67 and samarium-153 labeled conjugates for tumor radioimmunotherapy'. Together they form a unique fingerprint.

  • Cite this

    Srivastava, S. C., Mausner, L. F., Mease, R. C., Meinken, G. E., Joshi, V., Kolsky, K., Sweet, M., & Steplewski, Z. (1995). Development and evaluation of copper-67 and samarium-153 labeled conjugates for tumor radioimmunotherapy. International Journal of Pharmacognosy, 33(SUPPL.), 92-101.