Developing neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction

Jeffrey A. Rumbaugh, Joseph Steiner, Ned Sacktor, Avindra Nath

Research output: Contribution to journalArticle

Abstract

Important advances have been made in recent years in identifying the molecular mechanisms of HIV neuropathogenesis. Defining the pathways leading to HIV dementia has created an opportunity to therapeutically target many steps in the pathogenic process. HIV itself rarely infects neurons, but significant neuronal damage is caused both by viral proteins and by inflammatory mediators produced by the host in response to infection. Highly active antiretroviral therapy (HAART) does not target these mediators of neuronal damage, and the prevalence of HIV-associated neurocognitive dysfunction has actually been rising in the post-HAART era. This review will briefly summarize our current understanding of the mechanisms of HIV-induced neurological disease, and emphasize translation of this basic research into potential clinical applications.

Original languageEnglish (US)
Pages (from-to)271-280
Number of pages10
JournalFuture HIV Therapy
Volume2
Issue number3
DOIs
StatePublished - 2008

Fingerprint

HIV
Highly Active Antiretroviral Therapy
AIDS Dementia Complex
Viral Proteins
Therapeutics
Neurons
Infection
Research

Keywords

  • Cytokines
  • Excitotoxicity
  • Gp 120
  • HAART
  • HIV demenia
  • MMP
  • Nitrosative stress
  • Oxidative stress
  • Tat

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

Cite this

Developing neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction. / Rumbaugh, Jeffrey A.; Steiner, Joseph; Sacktor, Ned; Nath, Avindra.

In: Future HIV Therapy, Vol. 2, No. 3, 2008, p. 271-280.

Research output: Contribution to journalArticle

Rumbaugh, Jeffrey A. ; Steiner, Joseph ; Sacktor, Ned ; Nath, Avindra. / Developing neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction. In: Future HIV Therapy. 2008 ; Vol. 2, No. 3. pp. 271-280.
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