Developing imidazoles as CEST MRI pH sensors

Xing Yang, Xiaolei Song, Sangeeta Ray Banerjee, Yuguo Li, Youngjoo Byun, Guanshu Liu, Zaver M. Bhujwalla, Martin G. Pomper, Michael T. McMahon

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

A series of intra-molecular hydrogen bonded imidazoles and related heterocyclic compounds were screened for their N–H chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) contrast properties. Of the compounds, imidazole-4,5-dicarboxamides (I45DCs) were found to provide the strongest contrast, with the contrast produced at a large chemical shift from water (7.8 ppm) and strongly dependent on pH. We have tested several probes based on this scaffold, and demonstrated that these probes could be applied for in vivo detection of kidney pH after intravenous administration.

Original languageEnglish (US)
Pages (from-to)304-312
Number of pages9
JournalContrast Media and Molecular Imaging
Volume11
Issue number4
DOIs
StatePublished - Jul 1 2016

Keywords

  • chemical exchange saturation transfer
  • imidazole-4,5-dicarboxamides
  • molecular imaging
  • pH imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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