Developing biomimetic collagen-based matrix using cyclodextrin for corneal repair

Qiongyu Guo, Lucas Shores, Oliver Schein, Morgana M. Trexler, Jennifer H. Elisseeff

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The worldwide demand for corneal transplantations cannot match by the supply of donor corneas, especially in most developing countries. There is a large need of developing new corneal substitute mimicking the native cornea in terms of optical, biomechanical and biological properties. The cornea has four main types of proteoglycan that play a critical role in collagen fibrogenesis and transparency. However, obtaining purified proteoglycans has been a challenging task due to their high cost. In this study, we employed cyclodextrins as a proteoglycan substitute to engineer a biomimetic collagen-based matrix. The incorporation of cyclodextrin in collagen membrane increased collagen thermal stability and reduced collagen fibrogenesis. As a result, a thick, transparent and mechanically strong collagen-based membrane was formed. This cyclodextrin-collagen membrane holds a great potential to be used as a therapeutic eye patch for corneal repair.

Original languageEnglish (US)
Title of host publicationProceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479937288
DOIs
StatePublished - Dec 2 2014
Event2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014 - Boston, United States
Duration: Apr 25 2014Apr 27 2014

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
Volume2014-December
ISSN (Print)1071-121X
ISSN (Electronic)2160-7001

Other

Other2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
CountryUnited States
CityBoston
Period4/25/144/27/14

Keywords

  • collagen
  • corneal regeneration
  • cyclodextrin
  • fibrogenesis
  • proteoglycan

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Guo, Q., Shores, L., Schein, O., Trexler, M. M., & Elisseeff, J. H. (2014). Developing biomimetic collagen-based matrix using cyclodextrin for corneal repair. In Proceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014 [6972807] (Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC; Vol. 2014-December). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBEC.2014.6972807