Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Kaitlyn Sadtler, Kenneth Estrellas, Brian W. Allen, Matthew T. Wolf, Hongni Fan, Ada J. Tam, Chirag H. Patel, Brandon S. Luber, Hao Wang, Kathryn R. Wagner, Jonathan D. Powell, Franck Housseau, Drew M. Pardoll, Jennifer H. Elisseeff

Research output: Research - peer-reviewArticle

Abstract

Immune-mediated tissue regeneration driven by a biomaterial scaffold is emerging as an innovative regenerative strategy to repair damaged tissues. We investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration. The scaffolds induced a pro-regenerative response, characterized by an mTOR/Rictor-dependent T helper 2 pathway that guides interleukin-4-dependent macrophage polarization, which is critical for functional muscle recovery. Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.

LanguageEnglish (US)
Pages366-370
Number of pages5
JournalScience
Volume352
Issue number6283
DOIs
StatePublished - Apr 15 2016

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Th2 Cells
Biocompatible Materials
Regeneration
Muscles
Interleukin-4
Immune System
Macrophages
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Sadtler, K., Estrellas, K., Allen, B. W., Wolf, M. T., Fan, H., Tam, A. J., ... Elisseeff, J. H. (2016). Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells. Science, 352(6283), 366-370. DOI: 10.1126/science.aad9272

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells. / Sadtler, Kaitlyn; Estrellas, Kenneth; Allen, Brian W.; Wolf, Matthew T.; Fan, Hongni; Tam, Ada J.; Patel, Chirag H.; Luber, Brandon S.; Wang, Hao; Wagner, Kathryn R.; Powell, Jonathan D.; Housseau, Franck; Pardoll, Drew M.; Elisseeff, Jennifer H.

In: Science, Vol. 352, No. 6283, 15.04.2016, p. 366-370.

Research output: Research - peer-reviewArticle

Sadtler, K, Estrellas, K, Allen, BW, Wolf, MT, Fan, H, Tam, AJ, Patel, CH, Luber, BS, Wang, H, Wagner, KR, Powell, JD, Housseau, F, Pardoll, DM & Elisseeff, JH 2016, 'Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells' Science, vol 352, no. 6283, pp. 366-370. DOI: 10.1126/science.aad9272
Sadtler K, Estrellas K, Allen BW, Wolf MT, Fan H, Tam AJ et al. Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells. Science. 2016 Apr 15;352(6283):366-370. Available from, DOI: 10.1126/science.aad9272
Sadtler, Kaitlyn ; Estrellas, Kenneth ; Allen, Brian W. ; Wolf, Matthew T. ; Fan, Hongni ; Tam, Ada J. ; Patel, Chirag H. ; Luber, Brandon S. ; Wang, Hao ; Wagner, Kathryn R. ; Powell, Jonathan D. ; Housseau, Franck ; Pardoll, Drew M. ; Elisseeff, Jennifer H./ Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells. In: Science. 2016 ; Vol. 352, No. 6283. pp. 366-370
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