Detoxication of chemical carcinogens and chemoprevention

Melinda S. Yates, Thomas W. Kensler

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer chemoprevention is an approach that uses natural or synthetic agents, dietary supplements, or foods to block, retard, or even reverse the carcinogenic process. Modulation of the expression of enzymes affecting carcinogen detoxication, such as glutathione S-transferases and UDP-glucuronosyl transferases, is an effective means for cancer chemoprevention. This strategy seeks to alter carcinogen metabolism to facilitate elimination, resulting in protection against mutagenesis, carcinogenesis, and other forms of toxicity mediated by the reactive intermediates of carcinogens. This chapter describes the enzymes involved in carcinogen metabolism and detoxication, along with a discussion of agents that modulate their expression and their effects in animal models of carcinogenesis or human clinical trials.

Original languageEnglish (US)
Title of host publicationChemical Carcinogenesis
EditorsTrevor Penning
Pages159-179
Number of pages21
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

Publication series

NameCurrent Cancer Research
Volume6
ISSN (Print)0940-0745

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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