Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation

Robert Silbajoris, William Linak, Olga Shenderova, Christopher Winterrowd, Huan Cheng Chang, Jay L. Zweier, Anirudh Kota, Lisa A. Dailey, Nicholas Nunn, Philip A. Bromberg, James M. Samet

Research output: Contribution to journalArticle

Abstract

Detonation nanodiamonds (DNDs), a nanomaterial with an increasing range of industrial and biomedical applications, have previously been shown to induce a pro-inflammatory response in cultured human airway epithelial cells (HAECs). We now show that surface modifications induced by air oxidation of DND (AO-DND), including an increase in oxygen content, formation of carboxylic groups associated with the appearance of high negative zeta potential and a decrease in unpaired electron content, are accompanied by a significant loss of bioactivity, as measured by levels of interleukin-8 mRNA in HAEC. These findings are relevant to the identification of chemical determinants and molecular mechanisms of the inhalational toxicity of carbonaceous nanomaterials.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalDiamond and Related Materials
Volume58
DOIs
StatePublished - May 30 2015
Externally publishedYes

Fingerprint

Nanodiamonds
Detonation
detonation
Nanostructured materials
toxicity
Toxicity
interleukins
Oxidation
oxidation
air
Zeta potential
Air
Bioactivity
Interleukin-8
determinants
Surface treatment
Oxygen
Messenger RNA
Electrons
oxygen

Keywords

  • Human airway epithelial cells
  • Interleukin-8
  • Nanodiamond
  • Toxicity
  • Zeta potential

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Physics and Astronomy(all)
  • Chemistry(all)

Cite this

Silbajoris, R., Linak, W., Shenderova, O., Winterrowd, C., Chang, H. C., Zweier, J. L., ... Samet, J. M. (2015). Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation. Diamond and Related Materials, 58, 16-23. https://doi.org/10.1016/j.diamond.2015.05.007

Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation. / Silbajoris, Robert; Linak, William; Shenderova, Olga; Winterrowd, Christopher; Chang, Huan Cheng; Zweier, Jay L.; Kota, Anirudh; Dailey, Lisa A.; Nunn, Nicholas; Bromberg, Philip A.; Samet, James M.

In: Diamond and Related Materials, Vol. 58, 30.05.2015, p. 16-23.

Research output: Contribution to journalArticle

Silbajoris, R, Linak, W, Shenderova, O, Winterrowd, C, Chang, HC, Zweier, JL, Kota, A, Dailey, LA, Nunn, N, Bromberg, PA & Samet, JM 2015, 'Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation', Diamond and Related Materials, vol. 58, pp. 16-23. https://doi.org/10.1016/j.diamond.2015.05.007
Silbajoris, Robert ; Linak, William ; Shenderova, Olga ; Winterrowd, Christopher ; Chang, Huan Cheng ; Zweier, Jay L. ; Kota, Anirudh ; Dailey, Lisa A. ; Nunn, Nicholas ; Bromberg, Philip A. ; Samet, James M. / Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation. In: Diamond and Related Materials. 2015 ; Vol. 58. pp. 16-23.
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