TY - GEN
T1 - Determining vaccination status in the developing world using microneedle-delivered fluorescent microparticles
AU - McHugh, Kevin J.
AU - Jing, Lihong
AU - Severt, Sean Y.
AU - Cruz, Mache
AU - Jayawardena, Hapuarachchige Surangi N.
AU - Perkinson, Collin F.
AU - Sarmadi, Morteza
AU - Larusson, Fridrik
AU - Peters, Matthew
AU - Rose, Sviatlana
AU - Tomasic, Stephanie
AU - Graf, Tyler
AU - Tzeng, Stephany Y.
AU - Sugarman, James L.
AU - Peterson, Nels
AU - Langer, Robert
AU - Jaklenec, Ana
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Vaccines have been shown to be exceptionally safe and effective, yet each year 1.5 million people die due to vaccine-preventable infectious disease [1]. Challenges in terrain and availability of adequate tools in resource constrained settings often limit the effective distribution of vaccines, which can lead to reduced vaccine coverage rates [2]. One key barrier to improving vaccine coverage rates in low-resource settings is the lack of accurate immunization records. Because centralized databases of medical records do not exist in these areas, healthcare workers often rely on verbal communication with parents to determine vaccination status, which is often inaccurate leading to missed opportunities to vaccinate and wasted resources when additional unnecessary doses of vaccine are administered. To address this issue, we have developed an on-patient medical record using long-lived fluorescent microparticles, microneedles, and an adapted smartphone to determine vaccination status in the developing world. Our platform is designed to deliver both the vaccine and fluorescent particles in one form factor to streamline the administration process and be detectable for up to five years using a minimally-adapted smartphone.
AB - Statement of Purpose: Vaccines have been shown to be exceptionally safe and effective, yet each year 1.5 million people die due to vaccine-preventable infectious disease [1]. Challenges in terrain and availability of adequate tools in resource constrained settings often limit the effective distribution of vaccines, which can lead to reduced vaccine coverage rates [2]. One key barrier to improving vaccine coverage rates in low-resource settings is the lack of accurate immunization records. Because centralized databases of medical records do not exist in these areas, healthcare workers often rely on verbal communication with parents to determine vaccination status, which is often inaccurate leading to missed opportunities to vaccinate and wasted resources when additional unnecessary doses of vaccine are administered. To address this issue, we have developed an on-patient medical record using long-lived fluorescent microparticles, microneedles, and an adapted smartphone to determine vaccination status in the developing world. Our platform is designed to deliver both the vaccine and fluorescent particles in one form factor to streamline the administration process and be detectable for up to five years using a minimally-adapted smartphone.
UR - http://www.scopus.com/inward/record.url?scp=85065394646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065394646&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065394646
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 186
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -