Determining the in vivo transverse relaxation time of GABA in the human brain at 7T

Jarunee Intrapiromkul, He Zhu, Ying Cheng, Peter B Barker, Richard Anthony Edward Edden

Research output: Contribution to journalArticle

Abstract

Purpose To measure in vivo transverse relaxation times (T2) of gamma-aminobutyric acid (GABA) at 7T using the experimental spectral-editing method. Materials and Methods Experiments were performed at 7T in a 10 mM GABA phantom to determine the intrinsic TE-dependence of the edited signal. Then the same method was applied with editing-based suppression of coedited macromolecular signals to five healthy volunteers to determine T2 of GABA in vivo. Results From in vivo data acquired at multiple echo times, the in vivo GABA T2 relaxation time was estimated to be 63 ± 19 msec. Conclusion We present a measurement of the T2 of edited GABA signal at 7T by first using phantom measurements to determine the echo time-dependence of edited signal. The method is purely experimental and does not rely on prior knowledge of coupling constants or simulation of realistic experiments. J. Magn. Reson. Imaging 2013;38:1224-1229. © 2013 Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)1224-1229
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume38
Issue number5
DOIs
StatePublished - Nov 2013

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gamma-Aminobutyric Acid
Brain
Healthy Volunteers

Keywords

  • 7T
  • editing
  • GABA
  • magnetic resonance spectroscopy
  • T
  • transverse relaxation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Determining the in vivo transverse relaxation time of GABA in the human brain at 7T. / Intrapiromkul, Jarunee; Zhu, He; Cheng, Ying; Barker, Peter B; Edden, Richard Anthony Edward.

In: Journal of Magnetic Resonance Imaging, Vol. 38, No. 5, 11.2013, p. 1224-1229.

Research output: Contribution to journalArticle

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AU - Edden, Richard Anthony Edward

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N2 - Purpose To measure in vivo transverse relaxation times (T2) of gamma-aminobutyric acid (GABA) at 7T using the experimental spectral-editing method. Materials and Methods Experiments were performed at 7T in a 10 mM GABA phantom to determine the intrinsic TE-dependence of the edited signal. Then the same method was applied with editing-based suppression of coedited macromolecular signals to five healthy volunteers to determine T2 of GABA in vivo. Results From in vivo data acquired at multiple echo times, the in vivo GABA T2 relaxation time was estimated to be 63 ± 19 msec. Conclusion We present a measurement of the T2 of edited GABA signal at 7T by first using phantom measurements to determine the echo time-dependence of edited signal. The method is purely experimental and does not rely on prior knowledge of coupling constants or simulation of realistic experiments. J. Magn. Reson. Imaging 2013;38:1224-1229. © 2013 Wiley Periodicals, Inc.

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