Determination of thioproline in plasma using high performance liquid chromatography

Jan Lankelma; Paul G M Penders; Albert Leyva; Herbert M. Pinedo

doi:10.1016/0304-3835(81)90048-3

Determination of thioproline in plasma using high performance liquid chromatography

Jan Lankelma, Paul G M Penders, Albert Leyva, Herbert M. Pinedo

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The determination of thioproline in plasma of cancer patients, using high performance liquid chromatography (HPLC) is reported. As column support, a silica-bonded cation exchanger was used. Detection was performed at 205 nm. The detection limit of the method was 5 × 10^-6 M and the linear dynamic range was over 500. No sample clean-up procedure was necessary other than deproteinization of the plasma. The method was applied to the measurement of plasma drug levels in 3 patients, part of a clinical trial testing the effectiveness of thioproline as an anti-cancer agent.

Original language	English (US)
Pages (from-to)	131-137
Number of pages	7
Journal	Cancer Letters
Volume	12
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3835(81)90048-3
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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10.1016/0304-3835(81)90048-3

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title = "Determination of thioproline in plasma using high performance liquid chromatography",

abstract = "The determination of thioproline in plasma of cancer patients, using high performance liquid chromatography (HPLC) is reported. As column support, a silica-bonded cation exchanger was used. Detection was performed at 205 nm. The detection limit of the method was 5 × 10-6 M and the linear dynamic range was over 500. No sample clean-up procedure was necessary other than deproteinization of the plasma. The method was applied to the measurement of plasma drug levels in 3 patients, part of a clinical trial testing the effectiveness of thioproline as an anti-cancer agent.",

author = "Jan Lankelma and Penders, {Paul G M} and Albert Leyva and Pinedo, {Herbert M.}",

year = "1981",

doi = "10.1016/0304-3835(81)90048-3",

language = "English (US)",

volume = "12",

pages = "131--137",

journal = "Cancer Letters",

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T1 - Determination of thioproline in plasma using high performance liquid chromatography

AU - Lankelma, Jan

AU - Penders, Paul G M

AU - Leyva, Albert

AU - Pinedo, Herbert M.

PY - 1981

Y1 - 1981

N2 - The determination of thioproline in plasma of cancer patients, using high performance liquid chromatography (HPLC) is reported. As column support, a silica-bonded cation exchanger was used. Detection was performed at 205 nm. The detection limit of the method was 5 × 10-6 M and the linear dynamic range was over 500. No sample clean-up procedure was necessary other than deproteinization of the plasma. The method was applied to the measurement of plasma drug levels in 3 patients, part of a clinical trial testing the effectiveness of thioproline as an anti-cancer agent.

AB - The determination of thioproline in plasma of cancer patients, using high performance liquid chromatography (HPLC) is reported. As column support, a silica-bonded cation exchanger was used. Detection was performed at 205 nm. The detection limit of the method was 5 × 10-6 M and the linear dynamic range was over 500. No sample clean-up procedure was necessary other than deproteinization of the plasma. The method was applied to the measurement of plasma drug levels in 3 patients, part of a clinical trial testing the effectiveness of thioproline as an anti-cancer agent.

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VL - 12

SP - 131

EP - 137

JO - Cancer Letters

JF - Cancer Letters

IS - 1-2

ER -

Determination of thioproline in plasma using high performance liquid chromatography

Abstract

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