Determination of thioproline in plasma using high performance liquid chromatography

Jan Lankelma, Paul G M Penders, Albert Leyva, Herbert M. Pinedo

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The determination of thioproline in plasma of cancer patients, using high performance liquid chromatography (HPLC) is reported. As column support, a silica-bonded cation exchanger was used. Detection was performed at 205 nm. The detection limit of the method was 5 × 10-6 M and the linear dynamic range was over 500. No sample clean-up procedure was necessary other than deproteinization of the plasma. The method was applied to the measurement of plasma drug levels in 3 patients, part of a clinical trial testing the effectiveness of thioproline as an anti-cancer agent.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalCancer Letters
Issue number1-2
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology


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