Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy

Chen Wang, Chenxuan Wang, Xiaobo Mao, Aihua Yang, Lin Niu, Shengnan Wang, Denghua Li, Yuanyuan Guo, Yibing Wang, Yanlian Yang

Research output: Contribution to journalArticle

Abstract

The binding behaviour of labeling molecule copper phthalocyanine tetrasulfonate sodium (PcCu(SO 3Na) 4) on the assemblies of representative polyamino acids has been studied by using scanning tunneling microscopy (STM). By directly visualizing the adsorption and distribution of the labeling species on the peptide assemblies in STM images, one could obtain relative binding affinities of the labeling molecule with different amino acid residues.

Original languageEnglish (US)
Pages (from-to)10638-10640
Number of pages3
JournalChemical Communications
Volume47
Issue number38
DOIs
StatePublished - Oct 14 2011
Externally publishedYes

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Scanning tunneling microscopy
Labeling
Amino acids
Amino Acids
Molecules
Peptides
Sodium
Copper
Adsorption
Acids

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy. / Wang, Chen; Wang, Chenxuan; Mao, Xiaobo; Yang, Aihua; Niu, Lin; Wang, Shengnan; Li, Denghua; Guo, Yuanyuan; Wang, Yibing; Yang, Yanlian.

In: Chemical Communications, Vol. 47, No. 38, 14.10.2011, p. 10638-10640.

Research output: Contribution to journalArticle

Wang, Chen ; Wang, Chenxuan ; Mao, Xiaobo ; Yang, Aihua ; Niu, Lin ; Wang, Shengnan ; Li, Denghua ; Guo, Yuanyuan ; Wang, Yibing ; Yang, Yanlian. / Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy. In: Chemical Communications. 2011 ; Vol. 47, No. 38. pp. 10638-10640.
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