Determination of regional VA/Q by hyperpolarized 3He MRI

Rahim R. Rizi, James E. Baumgardner, Masaru Ishii, Zebulon Z. Spector, Johan M. Edvinsson, Aman Jalali, Jiangsheng Yu, Maxim Itkin, David A. Lipson, Warren Gefter

Research output: Contribution to journalArticlepeer-review

Abstract

Alveolar ventilation/perfusion ratio (VA/Q) is a, key parameter in functional imaging of the lung. Herein, regional VA/Q was calculated from regional values of alveolar partial pressure of oxygen (P AO2) measured by hyperpolarized 3He gas MRI (HP 3He MRI). Yorkshire pigs (n = 7, mean weight = 25 kg) were paralyzed and maintained under isoflurane anesthesia. Animals were placed into a birdcage coil, then transferred to the bore of a 1.5 T MRI unit. Prior to imaging, animals were manually ventilated with room air for 5 min, then a 3He gas mixture was administered during breathhold and imaging performed. P AO2 was measured based on the decay rate of 3He signal. Subjects' blood gas concentrations were measured and these values and PAO2 values entered into a system of four equations with four unknowns. Calculated VA/Q values were analyzed by preparing frequency distributions for the entire lung and compared to VA/Q frequency distributions previously established in the literature as normal using other diagnostic techniques. Distributions were consistent with those in the literature, indicating that HP 3He MRI may be an accurate, quantitative, noninvasive, and nonradioactive method for acquiring V A/Q for small regions of the lung.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
JournalMagnetic resonance in medicine
Volume52
Issue number1
DOIs
StatePublished - Jul 2004

Keywords

  • Assessment of lung function
  • Polarized gas MRI
  • Regional perfusion
  • Regional ventilation
  • V/Q ratio

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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