Determination of oxygen extraction ratios by magnetic resonance imaging

Joni M.E. Oja, Joseph S. Gillen, Risto A. Kauppinen, Michael Kraut, Peter C.M. Van Zijl

Research output: Contribution to journalArticlepeer-review

Abstract

The oxygen extraction ratio (OER) of a tissue describes the interplay between oxygen delivery and consumption and, as such, directly reflects the viability and activity of any organ. It is shown that OER can be quantified using a single magnetic resonance imaging observable, namely the relaxation time T2 of venous blood draining from the tissue. This principle is applied to study local OER changes in the brain on visual stimulation in humans, unambiguously demonstrating a mismatch between changes in blood flow and oxygen metabolism on activation.

Original languageEnglish (US)
Pages (from-to)1289-1295
Number of pages7
JournalJournal of Cerebral Blood Flow and Metabolism
Volume19
Issue number12
DOIs
StatePublished - 1999

Keywords

  • Magnetic resonance imaging
  • Mismatch
  • Oxygen extraction
  • Uncoupling

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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