Determination of oxygen extraction ratios by magnetic resonance imaging

Joni M.E. Oja; Joseph S. Gillen; Risto A. Kauppinen; Michael Kraut; Peter C.M. Van Zijl

doi:10.1097/00004647-199912000-00001

Determination of oxygen extraction ratios by magnetic resonance imaging

Joni M.E. Oja, Joseph S. Gillen, Risto A. Kauppinen, Michael Kraut, Peter C.M. Van Zijl

School of Medicine

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

The oxygen extraction ratio (OER) of a tissue describes the interplay between oxygen delivery and consumption and, as such, directly reflects the viability and activity of any organ. It is shown that OER can be quantified using a single magnetic resonance imaging observable, namely the relaxation time T₂ of venous blood draining from the tissue. This principle is applied to study local OER changes in the brain on visual stimulation in humans, unambiguously demonstrating a mismatch between changes in blood flow and oxygen metabolism on activation.

Original language	English (US)
Pages (from-to)	1289-1295
Number of pages	7
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	19
Issue number	12
DOIs	https://doi.org/10.1097/00004647-199912000-00001
State	Published - 1999

Keywords

Magnetic resonance imaging
Mismatch
Oxygen extraction
Uncoupling

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1097/00004647-199912000-00001

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AU - Gillen, Joseph S.

AU - Kauppinen, Risto A.

AU - Kraut, Michael

AU - Van Zijl, Peter C.M.

PY - 1999

Y1 - 1999

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AB - The oxygen extraction ratio (OER) of a tissue describes the interplay between oxygen delivery and consumption and, as such, directly reflects the viability and activity of any organ. It is shown that OER can be quantified using a single magnetic resonance imaging observable, namely the relaxation time T2 of venous blood draining from the tissue. This principle is applied to study local OER changes in the brain on visual stimulation in humans, unambiguously demonstrating a mismatch between changes in blood flow and oxygen metabolism on activation.

KW - Magnetic resonance imaging

KW - Mismatch

KW - Oxygen extraction

KW - Uncoupling

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Determination of oxygen extraction ratios by magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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