Determinants of virulence in the pathogenic fungi

Research output: Contribution to journalArticle

Abstract

To understand the origin of virulence among pathogenic fungus is important to consider both the host the ecologic riche of the microbe involved. Host-associated pathogenic fungi (eg commensals such as Candida albicans) generally cause disease only in situtations where there is a disruption of the host-microbe relationship. On the other hand, pathogenic fungi acquired from the environment typically cause disease in impaired hosts, after exposure to large infective inocula, and/or when a more virulent variant emerges. Animal and plant pathogenic fungi acquired from the environment probably face similar selection pressures from physical conditions, microbial competition and predators such as amoebae. For some human pathogenic fungi the determinants of virulence (virulence factors) appear to have been selected for environmental survival and function in mammalian virulence more by accident or happenstance, than design. Given that many emerging infectious diseases reflect interspecies and cross-kingdom jumps in pathogenicity an enhanced understanding of the determinants of virulence in animal and plant pathogenic fungi could help anticipate and prepare for future microbial threats.

Original languageEnglish (US)
Pages (from-to)130-132
Number of pages3
JournalFungal Biology Reviews
Volume21
Issue number4
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

animal pathogenic fungi
Virulence
Fungi
virulence
fungi
plant pathogenic fungi
microbial competition
microorganisms
Emerging Communicable Diseases
emerging diseases
Amoeba
accidents
Candida albicans
Virulence Factors
inoculum
pathogenicity
predators
Pressure
Survival

Keywords

  • Amoebae
  • Animal
  • Fungi
  • Infectious diseases
  • Pathogenicity
  • Plant
  • Virulence

ASJC Scopus subject areas

  • Plant Science
  • Microbiology

Cite this

Determinants of virulence in the pathogenic fungi. / Casadevall, Arturo.

In: Fungal Biology Reviews, Vol. 21, No. 4, 11.2007, p. 130-132.

Research output: Contribution to journalArticle

@article{4b0ac937bac54ee8b13b8e6e79e69ab0,
title = "Determinants of virulence in the pathogenic fungi",
abstract = "To understand the origin of virulence among pathogenic fungus is important to consider both the host the ecologic riche of the microbe involved. Host-associated pathogenic fungi (eg commensals such as Candida albicans) generally cause disease only in situtations where there is a disruption of the host-microbe relationship. On the other hand, pathogenic fungi acquired from the environment typically cause disease in impaired hosts, after exposure to large infective inocula, and/or when a more virulent variant emerges. Animal and plant pathogenic fungi acquired from the environment probably face similar selection pressures from physical conditions, microbial competition and predators such as amoebae. For some human pathogenic fungi the determinants of virulence (virulence factors) appear to have been selected for environmental survival and function in mammalian virulence more by accident or happenstance, than design. Given that many emerging infectious diseases reflect interspecies and cross-kingdom jumps in pathogenicity an enhanced understanding of the determinants of virulence in animal and plant pathogenic fungi could help anticipate and prepare for future microbial threats.",
keywords = "Amoebae, Animal, Fungi, Infectious diseases, Pathogenicity, Plant, Virulence",
author = "Arturo Casadevall",
year = "2007",
month = "11",
doi = "10.1016/j.fbr.2007.02.007",
language = "English (US)",
volume = "21",
pages = "130--132",
journal = "Fungal Biology Reviews",
issn = "1749-4613",
publisher = "Elsevier BV",
number = "4",

}

TY - JOUR

T1 - Determinants of virulence in the pathogenic fungi

AU - Casadevall, Arturo

PY - 2007/11

Y1 - 2007/11

N2 - To understand the origin of virulence among pathogenic fungus is important to consider both the host the ecologic riche of the microbe involved. Host-associated pathogenic fungi (eg commensals such as Candida albicans) generally cause disease only in situtations where there is a disruption of the host-microbe relationship. On the other hand, pathogenic fungi acquired from the environment typically cause disease in impaired hosts, after exposure to large infective inocula, and/or when a more virulent variant emerges. Animal and plant pathogenic fungi acquired from the environment probably face similar selection pressures from physical conditions, microbial competition and predators such as amoebae. For some human pathogenic fungi the determinants of virulence (virulence factors) appear to have been selected for environmental survival and function in mammalian virulence more by accident or happenstance, than design. Given that many emerging infectious diseases reflect interspecies and cross-kingdom jumps in pathogenicity an enhanced understanding of the determinants of virulence in animal and plant pathogenic fungi could help anticipate and prepare for future microbial threats.

AB - To understand the origin of virulence among pathogenic fungus is important to consider both the host the ecologic riche of the microbe involved. Host-associated pathogenic fungi (eg commensals such as Candida albicans) generally cause disease only in situtations where there is a disruption of the host-microbe relationship. On the other hand, pathogenic fungi acquired from the environment typically cause disease in impaired hosts, after exposure to large infective inocula, and/or when a more virulent variant emerges. Animal and plant pathogenic fungi acquired from the environment probably face similar selection pressures from physical conditions, microbial competition and predators such as amoebae. For some human pathogenic fungi the determinants of virulence (virulence factors) appear to have been selected for environmental survival and function in mammalian virulence more by accident or happenstance, than design. Given that many emerging infectious diseases reflect interspecies and cross-kingdom jumps in pathogenicity an enhanced understanding of the determinants of virulence in animal and plant pathogenic fungi could help anticipate and prepare for future microbial threats.

KW - Amoebae

KW - Animal

KW - Fungi

KW - Infectious diseases

KW - Pathogenicity

KW - Plant

KW - Virulence

UR - http://www.scopus.com/inward/record.url?scp=36549053119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36549053119&partnerID=8YFLogxK

U2 - 10.1016/j.fbr.2007.02.007

DO - 10.1016/j.fbr.2007.02.007

M3 - Article

C2 - 19513186

AN - SCOPUS:36549053119

VL - 21

SP - 130

EP - 132

JO - Fungal Biology Reviews

JF - Fungal Biology Reviews

SN - 1749-4613

IS - 4

ER -