Determinants of systemic zero-flow arterial pressure.

M. J. Brunner, A. S. Greene, K. Sagawa, Artin A Shoukas

Research output: Contribution to journalArticle

Abstract

Thirteen pentobarbital-anesthetized dogs whose carotid sinuses were isolated and perfused at a constant pressure were placed on total cardiac bypass. With systemic venous pressure held at 0 mmHg (condition 1), arterial inflow was stopped for 20 s at intrasinus pressures of 50, 125, and 200 mmHg. Zero-flow arterial pressures under condition 1 were 16.2 +/- 1.3 (SE), 13.8 +/- 1.1, and 12.5 +/- 0.8 mmHg, respectively. In condition 2, the venous outflow tube was clamped at the instant of stopping the inflow, causing venous pressure to rise. The zero-flow arterial pressures were 19.7 +/- 1.3, 18.5 +/- 1.4, and 16.4 +/- 1.2 mmHg for intrasinus pressures of 50, 125, and 200 mmHg, respectively. At all levels of intrasinus pressure, the zero-flow arterial pressure in condition 2 was higher (P less than 0.005) than in condition 1. In seven dogs, at an intrasinus pressure of 125 mmHg, epinephrine increased the zero-flow arterial pressure by 3.0 mmHg, whereas hexamethonium and papaverine decreased the zero-flow arterial pressure by 2 mmHg. Reductions in the hematocrit from 52 to 11% resulted in statistically significant changes (P less than 0.01) in zero-flow arterial pressures. Thus zero-flow arterial pressure was found to be affected by changes in venous pressure, hematocrit, and vasomotor tone. The evidence does not support the literally interpreted concept of the vascular waterfall as the model for the finite arteriovenous pressure difference at zero flow.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume245
Issue number3
StatePublished - Sep 1983

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Arterial Pressure
Pressure
Venous Pressure
Hematocrit
Dogs
Carotid Sinus
Hexamethonium
Papaverine
Pentobarbital
Epinephrine
Blood Vessels

ASJC Scopus subject areas

  • Medicine(all)

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Determinants of systemic zero-flow arterial pressure. / Brunner, M. J.; Greene, A. S.; Sagawa, K.; Shoukas, Artin A.

In: The American journal of physiology, Vol. 245, No. 3, 09.1983.

Research output: Contribution to journalArticle

Brunner, M. J. ; Greene, A. S. ; Sagawa, K. ; Shoukas, Artin A. / Determinants of systemic zero-flow arterial pressure. In: The American journal of physiology. 1983 ; Vol. 245, No. 3.
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