Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe

Laura E. Smith, Mduduzi N.N. Mbuya, Andrew J. Prendergast, Paul C. Turner, Sandra Ruboko, Jean Hawes Humphrey, Rebecca J. Nelson, Ancikaria Chigumira, George Kembo, Rebecca J. Stoltzfus

Research output: Contribution to journalArticle

Abstract

Scope: Aflatoxins (AFs) are toxic secondary metabolites of Aspergillus species that contaminate staple foods such as maize and groundnuts. AF exposure during pregnancy has been associated with adverse birth outcomes in limited-scale surveys in sub-Saharan Africa. The objective of this study was to describe the determinants of AF exposure, using urinary aflatoxin M1 (AFM1) biomarkers and data generated by the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial for rural Zimbabwean women in early pregnancy. Sanitation Hygiene Infant Nutrition Efficacy is a large, cluster-randomized community-based trial in Zimbabwe designed to investigate the independent and combined effects of nutrition and hygiene interventions on early child growth. Methods and results: Urine samples collected from 1580 pregnant women in rural Zimbabwe at median gestational age of 13.9 wk were measured for AFM1. AFM1 was detected in 30% of samples (median of exposed, 162 pg AFM1/mg creatinine; range 30-6046 pg AFM1/mg). In multivariable ordinal logistic models, geographical location (p<0.001), seasonality (p < 0.001) and dietary practices (p = 0.011) were significant predictors of urinary AFM1. Conclusion: This is the largest AF biomarker survey conducted in Zimbabwe, and demonstrated frequent exposure in pregnant women with clear temporal and spatial variability in AF biomarker levels.

Original languageEnglish (US)
JournalMolecular Nutrition and Food Research
DOIs
StateAccepted/In press - 2017

Fingerprint

Aflatoxin M1
aflatoxin M1
Zimbabwe
Aflatoxins
pregnant women
aflatoxins
Pregnant Women
Hygiene
hygiene
infant nutrition
biomarkers
Sanitation
Biomarkers
sanitation
pregnancy
rural women
child growth
Pregnancy
Africa South of the Sahara
staple foods

Keywords

  • Aflatoxin
  • Dietary diversity
  • Pregnancy
  • Spatial variation
  • Temporal variation

ASJC Scopus subject areas

  • Biotechnology
  • Food Science

Cite this

Smith, L. E., Mbuya, M. N. N., Prendergast, A. J., Turner, P. C., Ruboko, S., Humphrey, J. H., ... Stoltzfus, R. J. (Accepted/In press). Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201601049

Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe. / Smith, Laura E.; Mbuya, Mduduzi N.N.; Prendergast, Andrew J.; Turner, Paul C.; Ruboko, Sandra; Humphrey, Jean Hawes; Nelson, Rebecca J.; Chigumira, Ancikaria; Kembo, George; Stoltzfus, Rebecca J.

In: Molecular Nutrition and Food Research, 2017.

Research output: Contribution to journalArticle

Smith, LE, Mbuya, MNN, Prendergast, AJ, Turner, PC, Ruboko, S, Humphrey, JH, Nelson, RJ, Chigumira, A, Kembo, G & Stoltzfus, RJ 2017, 'Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe', Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201601049
Smith, Laura E. ; Mbuya, Mduduzi N.N. ; Prendergast, Andrew J. ; Turner, Paul C. ; Ruboko, Sandra ; Humphrey, Jean Hawes ; Nelson, Rebecca J. ; Chigumira, Ancikaria ; Kembo, George ; Stoltzfus, Rebecca J. / Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe. In: Molecular Nutrition and Food Research. 2017.
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abstract = "Scope: Aflatoxins (AFs) are toxic secondary metabolites of Aspergillus species that contaminate staple foods such as maize and groundnuts. AF exposure during pregnancy has been associated with adverse birth outcomes in limited-scale surveys in sub-Saharan Africa. The objective of this study was to describe the determinants of AF exposure, using urinary aflatoxin M1 (AFM1) biomarkers and data generated by the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial for rural Zimbabwean women in early pregnancy. Sanitation Hygiene Infant Nutrition Efficacy is a large, cluster-randomized community-based trial in Zimbabwe designed to investigate the independent and combined effects of nutrition and hygiene interventions on early child growth. Methods and results: Urine samples collected from 1580 pregnant women in rural Zimbabwe at median gestational age of 13.9 wk were measured for AFM1. AFM1 was detected in 30{\%} of samples (median of exposed, 162 pg AFM1/mg creatinine; range 30-6046 pg AFM1/mg). In multivariable ordinal logistic models, geographical location (p<0.001), seasonality (p < 0.001) and dietary practices (p = 0.011) were significant predictors of urinary AFM1. Conclusion: This is the largest AF biomarker survey conducted in Zimbabwe, and demonstrated frequent exposure in pregnant women with clear temporal and spatial variability in AF biomarker levels.",
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