Determinants of p, p'-Dichlorodiphenyldichloroethane (DDE) Concentration in Adipose Tissue in Women from Five European Cities

M. Inmaculada Sanz-gallardo, Eliseo Guallar, José M. Martín-moreno, Pieter Van 'T Veer, Frans J. Kok, Matthew P. Longnecker, J. J. Strain, Blaise C. Martin, Alwine F.M. Kardinaal, Joaquín Fernández-Crehuet, Michael Thamm, Lenore Kohlmeier

Research output: Contribution to journalArticlepeer-review

Abstract

To identify the determinants of p, p'-dichlorodiphenyldichloroethane (p, p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p, p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p, p'-DDE concentration was 1.66 μg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p, p'-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log10(p, p'-DDE). In our subjects, adipose tissue p, p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p, p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalArchives of Environmental Health
Volume54
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint Dive into the research topics of 'Determinants of p, p'-Dichlorodiphenyldichloroethane (DDE) Concentration in Adipose Tissue in Women from Five European Cities'. Together they form a unique fingerprint.

Cite this