To identify the determinants of p, p'-dichlorodiphenyldichloroethane (p, p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p, p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p, p'-DDE concentration was 1.66 μg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p, p'-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log10(p, p'-DDE). In our subjects, adipose tissue p, p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p, p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.
ASJC Scopus subject areas
- Environmental Chemistry
- Environmental Science(all)
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis