TY - JOUR
T1 - Determinants of p, p'-Dichlorodiphenyldichloroethane (DDE) Concentration in Adipose Tissue in Women from Five European Cities
AU - Sanz-gallardo, M. Inmaculada
AU - Guallar, Eliseo
AU - Martín-moreno, José M.
AU - Van 'T Veer, Pieter
AU - Kok, Frans J.
AU - Longnecker, Matthew P.
AU - Strain, J. J.
AU - Martin, Blaise C.
AU - Kardinaal, Alwine F.M.
AU - Fernández-Crehuet, Joaquín
AU - Thamm, Michael
AU - Kohlmeier, Lenore
N1 - Funding Information:
The EURAMIC Study was supported as an European Community Concerted Action by the Commission of the European Communities (contracts number MR4*/265/NL and MR4*/CT91/0369[SSMA]).T he DDE analyses were supported by EC DG-V ”Europe Against Cancer” (Grants No. 2216 and SOC 97 200292). The national studies were financed by grants from the Dutch Ministry of Health, the Spanish ”Fondo de lnvestigaciones Sanitarias” (91E 0575), the German Federal Health Office, the Swiss Cancer Research Foundation (AKT76), the Swiss National Science Foundation (32-9257-87), the Ulster Cancer Foundation and Milk Intervention Board (co-responsibility Levy Disbursement Reg EEC 110/90 Contract 77.2). Dr. M lnmaculada Sanz-Gallardo was supported by a grant from Spain’s “lnstituto de Salud Carlos 111” (FIS 97/4252).
PY - 1999
Y1 - 1999
N2 - To identify the determinants of p, p'-dichlorodiphenyldichloroethane (p, p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p, p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p, p'-DDE concentration was 1.66 μg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p, p'-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log10(p, p'-DDE). In our subjects, adipose tissue p, p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p, p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.
AB - To identify the determinants of p, p'-dichlorodiphenyldichloroethane (p, p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p, p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p, p'-DDE concentration was 1.66 μg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p, p'-DDE) were center of recruitment (p <.0001), adipose arachidic acid (p =.001), and adipose retinol (p =.04). These factors explained 14.9% of the overall variability of log10(p, p'-DDE). In our subjects, adipose tissue p, p'-DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p, p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.
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U2 - 10.1080/00039899909602486
DO - 10.1080/00039899909602486
M3 - Article
C2 - 10433187
AN - SCOPUS:0032809492
SN - 0003-9896
VL - 54
SP - 277
EP - 283
JO - Archives of Environmental Health
JF - Archives of Environmental Health
IS - 4
ER -