Determinants of neuronal vulnerability in neurodegenerative diseases

Brett Morrison, Patrick R. Hof, John H. Morrison

Research output: Contribution to journalArticle

Abstract

Selective neuronal vulnerability can be defined anatomically by the differential vulnerability of circuits and neurochemically by the vulnerability of neurons that differentially express particular proteins. The anatomic perspective is exemplified by the vulnerability of the nigrostriatal projection in Parkinson's disease (PD), the degeneration of upper and lower motor neurons in amyotrophic lateral sclerosis (ALS), and the preferential loss of long corticocortical projections in Alzheimer's disease (AD). The neurochemical perspective is reflected in the heightened vulnerability of neurons that normally express high somatodendritic levels of neurofilament (eg, entorhinal and association cortices in AD, the spinal cord in a mouse model of ALS, and the retina in a primate model of glaucoma), as well as the reduced vulnerability of neurons that express calcium-binding proteins (eg, neocortex of AD patients, the spinal cord and brainstem of ALS patients, and the spinal cord of a mouse model of ALS). By combining neurochemical and anatomic correlates of vulnerability, an integrated view of vulnerable neurons is emerging in which characteristics of vulnerable neurons appear to transcend both brain region and disease state, suggesting that neurodegenerative disorders share common mechanisms of degeneration.

Original languageEnglish (US)
JournalAnnals of Neurology
Volume44
Issue number3 SUPPL. 1
StatePublished - Sep 1998
Externally publishedYes

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Neurodegenerative Diseases
Amyotrophic Lateral Sclerosis
Neurons
Spinal Cord
Alzheimer Disease
Entorhinal Cortex
Calcium-Binding Proteins
Intermediate Filaments
Neocortex
Brain Diseases
Motor Neurons
Glaucoma
Primates
Brain Stem
Parkinson Disease
Retina
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Determinants of neuronal vulnerability in neurodegenerative diseases. / Morrison, Brett; Hof, Patrick R.; Morrison, John H.

In: Annals of Neurology, Vol. 44, No. 3 SUPPL. 1, 09.1998.

Research output: Contribution to journalArticle

Morrison, Brett ; Hof, Patrick R. ; Morrison, John H. / Determinants of neuronal vulnerability in neurodegenerative diseases. In: Annals of Neurology. 1998 ; Vol. 44, No. 3 SUPPL. 1.
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